USP28

Gene Symbol	USP28
Entrez Gene	57646
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	ubiquitin specific peptidase 28
Other Description	deubiquitinating enzyme 28|ubiquitin carboxyl-terminal hydrolase 28|ubiquitin carboxyl-terminal hydrolase 28 variant 1|ubiquitin specific protease 28|ubiquitin thioesterase 28|ubiquitin thiolesterase 28|ubiquitin-specific-processing protease 28
Swissprots	Q96RU2 B0YJC0 Q6NZX9 Q9P213 B0YJC1
Accessions	ACA06098 ACA06099 CCQ43656 EAW67231 EAW67232 EAW67233 EAW67234 EAW67235 Q96RU2 AB040948 BAA96039 AF266283 AAK58565 AK027521 BAB55172 AK097623 AK304376 BAG65214 AK304770 BAG65525 BC035986 BC065928 AAH65928 BF434481 BU940680 CD704003 DB061316 XM_005271630 XP_005271687 XM_005271631 XP_005271688 XM_005271632 XP_005271689 XM_005271633 XP_005271690 XM_005271636 XP_005271693 XM_005271637 XP_005271694 XM_005271638 XP_005271695 XM_005271639 XP_005271696 XM_011542936 XP_011541238 XM_011542937 XP_011541239 XM_011542938 XP_011541240 XM_011542939 XP_011541241 XM_011542940 XP_011541242 XM_011542941 XP_011541243 XM_011542942 XP_011541244 NM_001301029 NP_001287958 NM_020886 NP_065937
Function	Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus. {ECO:0000269|PubMed:16901786, ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:17873522, ECO:0000269|PubMed:18662541}.
Subcellular Location	Nucleus, nucleoplasm {ECO:0000269|PubMed:17558397}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human USP28 full length protein - ab188695 from Abcam Category Protein Prices $572.00 Sizes 100 µg Source Baculovirus infected Sf21 cells Species Human

Human USP28 full length protein - ab163618 from Abcam Category Protein Source Wheat germ Species Human

Human USP28 protein fragment - ab163619 from Abcam Category Protein Source Wheat germ Species Human

USP28 Antibody Blocking Peptide - LS-E26767 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

USP28 Antibody Blocking Peptide - LS-E6901 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human USP28 Protein - H00057646-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human USP28 Protein - H00057646-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

USP28 Peptide - P0955 from Novus Biologicals Category Peptide Species Human

USP28-Antibody-N-term-Blocking-Peptide - BP2152a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

USP28 (C-term) blocking peptide - GTX25086-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

USP28 blocking peptide - GTX88638-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Bovine

Recombinant Human His6-USP28, CF - E-570-100 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Contains a C-terminal 6-His tag

USP28 Peptide - AC21-1603-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

USP28 - H00057646-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

USP28 - H00057646-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

USP28 - H00057646-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

USP28 - H00057646-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

USP28 Peptide - 46-562P from ProSci Category Peptide Species Human

USP28 fusion protein - Ag12003 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

USP28 fusion protein - Ag11805 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human USP28, GST-tagged - USP28-3624H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human USP28, GST-tagged - USP28-188H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human USP28, His-tagged - USP28-152H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human Ubiquitin carboxyl-terminal hydrolase 28(USP28) ,partial - CSB-YP850427HU CSB-EP850427HU CSB-BP850427HU CSB-MP850427HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human His6-USP28 Protein, CF - E-570 from R&D Systems Category Protein Prices $269.00 Sizes 100 µg Source Spodoptera frugiperda , Sf 21 (baculovirus)-derived Contains a C-terminal 6-His tag Species Human

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