USP28

Gene Symbol USP28
Entrez Gene 57646
Alt Symbol -
Species Human
Gene Type protein-coding
Description ubiquitin specific peptidase 28
Other Description deubiquitinating enzyme 28|ubiquitin carboxyl-terminal hydrolase 28|ubiquitin carboxyl-terminal hydrolase 28 variant 1|ubiquitin specific protease 28|ubiquitin thioesterase 28|ubiquitin thiolesterase 28|ubiquitin-specific-processing protease 28
Swissprots Q96RU2 B0YJC0 Q6NZX9 Q9P213 B0YJC1
Accessions ACA06098 ACA06099 CCQ43656 EAW67231 EAW67232 EAW67233 EAW67234 EAW67235 Q96RU2 AB040948 BAA96039 AF266283 AAK58565 AK027521 BAB55172 AK097623 AK304376 BAG65214 AK304770 BAG65525 BC035986 BC065928 AAH65928 BF434481 BU940680 CD704003 DB061316 XM_005271630 XP_005271687 XM_005271631 XP_005271688 XM_005271632 XP_005271689 XM_005271633 XP_005271690 XM_005271636 XP_005271693 XM_005271637 XP_005271694 XM_005271638 XP_005271695 XM_005271639 XP_005271696 XM_011542936 XP_011541238 XM_011542937 XP_011541239 XM_011542938 XP_011541240 XM_011542939 XP_011541241 XM_011542940 XP_011541242 XM_011542941 XP_011541243 XM_011542942 XP_011541244 NM_001301029 NP_001287958 NM_020886 NP_065937
Function Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus. {ECO:0000269|PubMed:16901786, ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:17873522, ECO:0000269|PubMed:18662541}.
Subcellular Location Nucleus, nucleoplasm {ECO:0000269|PubMed:17558397}.

USP28 Antibody - 4217 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from COS cells, untransfected or transfected with mouse USP28, using USP28 Antibody.

USP28 (C-17) - sc-79312 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-USP28 antibody - ab188240 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-USP28 antibody (ab188240) at 1/2000 dilutionLane 1 : Lysate from U2OS cells transfected with a control siLane 2 : Lysate from U2OS cells transfected with a USP28 siLane 3 : NIH 3T3 cell lysateLane 4 : INS-1 cell lysateLysates/proteins at 40 µg per lane.

Anti-USP28 antibody - ab70893 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human ovarian carcinoma tissue labelling USP28 with ab70893 at 1/1000 (0.2µg/ml). Detection: DAB.

Anti-USP28 antibody - ab130351 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
ab130351, at 3.8 &microg/ml staining USP28 in paraffin-embedded Human testis tissue by Immunohistochemistry, with Alkaline Phosphatase detection.

Anti-USP28 antibody - ab70894 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human ovarian carcinoma tissue labelling USP28 with ab70894 at 1/5000 (0.2µg/ml). Detection: DAB.

Anti-USP28 antibody - ab84514 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab84514 at 1/250 dilution staining USP28 in human colon adenocarcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining.

Anti-USP28 antibody - ab169471 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-USP28 antibody (ab169471) at 1 µg/mlLane 1 : USP28 transfected 293T cell lysate Lane 2 : Non-transfected 293T cell lysate Lysates/proteins at 15 µl per lane.developed using the ECL technique

Anti-USP28 antibody - ab138722 from Abcam

Prices $376.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human testis tissue labelling USP28 with ab138722 at 3.8 µg/ml.

Anti-USP28 antibody [EPR4249(2)] - ab126604 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4249(2)
All lanes : Anti-USP28 antibody [EPR4249(2)] (ab126604) at 1/1000 dilutionLane 1 : 293T cell lysateLane 2 : HeLa cell lysateLane 3 : HT1376 cell lysateLane 4 : Human heart tissue lysateLane 5 : SW480 cell lysateLane 6 : A431 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-Rabbit HRP at 1/2000 dilution

Anti-USP28 antibody [EPR4250(2)] - ab110744 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4250(2)
All lanes : Anti-USP28 antibody [EPR4250(2)] (ab110744) at 1/1000 dilutionLane 1 : 293T cell lysateLane 2 : SW480 cell lysateLane 3 : HeLa cell lysateLane 4 : A431 cell lysateLysates/proteins at 10 µg per lane.

Anti-USP28 antibody - C-terminal - ab137438 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-USP28 antibody - C-terminal (ab137438) at 1/500 dilution + A431 whole cell lysate at 30 µg

Anti-USP28 Antibody (Internal, clone EPR4250(2)) - LS-C138372 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4250(2)
Western blot analysis on (A) 293T, (B) SW480, (C) HeLa, and (D) A431 cell lysates using anti-USP28 antibody.

Anti-USP28 Antibody (aa111-141) - LS-C99574 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
The anti-USP28 antibody is used in Western blot to detect USP28 in Jurkat cell lysate.

Anti-USP28 Antibody (Internal, clone EPR4249(2)) - LS-C152286 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4249(2)
Immunofluorescent staining of HeLa cells using anti-USP28 antibody.

Anti-USP28 Antibody (C-Terminus, PE) - LS-C226680 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP28 Antibody (aa50-100) - LS-C287737 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human USP28 by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-USP28 used at a dilution of 1:1000 (0.2 ug/ml). Detection: DAB.

Anti-USP28 Antibody (aa50-100) - LS-C286436 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human USP28 by Immunohistochemistry. Sample: FFPE section of human stomach adenocarcinoma. Antibody: Affinity purified rabbit anti-USP28 used at a dilution of 1:250.

Anti-USP28 Antibody (aa500-550) - LS-C286030 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human USP28 by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-USP28 used at a dilution of 1:5000 (0.2 ug/ml). Detection: DAB.

Anti-USP28 Antibody (aa674-685) IHC-plus™ - LS-B6475 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-USP28 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6475 concentration 2.5 ug/ml.

Anti-USP28 Antibody (aa50-100) - LS-C91874 from LifeSpan Bioscience

Prices $545.00
Sizes 20 µg
Host Rabbit
Clonality Polyclonal

Anti-USP28 Antibody (N-Terminus, AP) - LS-C226667 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP28 Antibody (N-Terminus, APC) - LS-C226668 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP28 Antibody (N-Terminus, Biotin) - LS-C226669 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP28 Antibody (N-Terminus, FITC) - LS-C226670 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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