CNGA3
| Gene Symbol | CNGA3 |
|---|---|
| Entrez Gene | 1261 |
| Alt Symbol | ACHM2, CCNC1, CCNCa, CCNCalpha, CNCG3, CNG3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cyclic nucleotide gated channel alpha 3 |
| Other Description | CNG channel alpha-3|CNG-3|cone photoreceptor cGMP-gated channel alpha subunit|cone photoreceptor cGMP-gated channel subunit alpha|cyclic nucleotide-gated cation channel alpha-3|cyclic nucleotide-gated channel alpha-3 |
| Swissprots | Q6ZNA7 Q4VAP7 Q9UP64 E9PF93 Q53RD2 Q16281 |
| Accessions | AAD14208 AAY24181 EAX01911 Q16281 AF065314 AAC17440 AK131300 BAD18468 AK308149 BC096298 AAH96298 BC096299 AAH96299 BC096300 AAH96300 DQ067459 DQ067460 DQ067461 DQ426863 DQ426864 DR002103 KJ650082 AIT55915 XM_006712243 XP_006712306 XM_011510554 XP_011508856 NM_001079878 NP_001073347 NM_001298 NP_001289 |
| Function | Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. {ECO:0000250, ECO:0000269|PubMed:10888875}. |
| Subcellular Location | Membrane; Multi-pass membrane protein. |
| Tissue Specificity | Prominently expressed in retina. |
| Top Pathways | Olfactory transduction, cAMP signaling pathway |
Anti-CNG3 antibody - ab87490 from Abcam
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Anti-CNG3 antibody - ab97500 from Abcam
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Anti-CNGA3 Antibody (N-Terminus) - LS-C14512 from LifeSpan Bioscience
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Anti-CNGA3 Antibody (aa395-413) - LS-C46933 from LifeSpan Bioscience
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Anti-CNGA3 Antibody (C-Terminus) - LS-C14514 from LifeSpan Bioscience
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Anti-CNGA3 Antibody - LS-C335319 from LifeSpan Bioscience
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CNGA3 Antibody - NBP1-46273 from Novus Biologicals
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Anti-CNGA3 (1-15) antibody produced in rabbit - SAB1104751 from Sigma-Aldrich
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Anti-CNGA3 (86-100) antibody produced in rabbit - SAB1104752 from Sigma-Aldrich
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CNGA3 antibody [N3C3] - GTX105162 from GeneTex
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CNGA3 antibody - 70R-16470 from Fitzgerald
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Anti -CNGA3 (Cyclic Nucleotide-gated Cation Channel alpha 3, CNG3, ACHM2, CCNC1, CCNCa,CNCG3, CCNCalpha) - 210184 from USBiological Life Science
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CNGA3 Polyclonal Antibody - A3288 from ABclonal
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CNG3 antibody - orb156413 from Biorbyt
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CNGA3 Antibody - abx002337 from Abbexa
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CNGA3 antibody - 21657-1-AP from Acris Antibodies
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Anti-CNGA3, Polyclonal Antibody - 25-A3288 from ARP American Research Products
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CNGA3 antibody - 21657-1-AP from Proteintech Group
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CNGA3 antibody - STJ23181 from St John's Laboratory Ltd
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Anti-CNGA3 antibody - STJ28968 from St John's Laboratory Ltd
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Anti-CNGA3 antibody - STJ23180 from St John's Laboratory Ltd
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CNG3, Polyclonal Antibody - MBS613699 from MyBioSource
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CNG3, Polyclonal Antibody - MBS618571 from MyBioSource
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CNGA3 - A3288 from NeoScientific
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CNGA3 Antibody - 35689 from Signalway Antibody
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