CNGA3
| Gene Symbol | CNGA3 |
|---|---|
| Entrez Gene | 1261 |
| Alt Symbol | ACHM2, CCNC1, CCNCa, CCNCalpha, CNCG3, CNG3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cyclic nucleotide gated channel alpha 3 |
| Other Description | CNG channel alpha-3|CNG-3|cone photoreceptor cGMP-gated channel alpha subunit|cone photoreceptor cGMP-gated channel subunit alpha|cyclic nucleotide-gated cation channel alpha-3|cyclic nucleotide-gated channel alpha-3 |
| Swissprots | Q6ZNA7 Q4VAP7 Q9UP64 E9PF93 Q53RD2 Q16281 |
| Accessions | AAD14208 AAY24181 EAX01911 Q16281 AF065314 AAC17440 AK131300 BAD18468 AK308149 BC096298 AAH96298 BC096299 AAH96299 BC096300 AAH96300 DQ067459 DQ067460 DQ067461 DQ426863 DQ426864 DR002103 KJ650082 AIT55915 XM_006712243 XP_006712306 XM_011510554 XP_011508856 NM_001079878 NP_001073347 NM_001298 NP_001289 |
| Function | Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. {ECO:0000250, ECO:0000269|PubMed:10888875}. |
| Subcellular Location | Membrane; Multi-pass membrane protein. |
| Tissue Specificity | Prominently expressed in retina. |
| Top Pathways | Olfactory transduction, cAMP signaling pathway |
CNG-3 CRISPR/Cas9 KO Plasmid (h) - sc-405352 from Santa Cruz Biotechnology
|
||||||||
CNG-3 HDR Plasmid (h) - sc-405352-HDR from Santa Cruz Biotechnology
|
||||||||
CNG-3 Double Nickase Plasmid (h) - sc-405352-NIC from Santa Cruz Biotechnology
|
||||||||
CNG-3 Double Nickase Plasmid (h2) - sc-405352-NIC-2 from Santa Cruz Biotechnology
|
||||||||
CNG-3 CRISPR Activation Plasmid (h) - sc-405352-ACT from Santa Cruz Biotechnology
|
||||||||
CNG-3 CRISPR Activation Plasmid (h2) - sc-405352-ACT-2 from Santa Cruz Biotechnology
|
||||||||
CNG-3 Lentiviral Activation Particles (h) - sc-405352-LAC from Santa Cruz Biotechnology
|
||||||||
CNG-3 Lentiviral Activation Particles (h2) - sc-405352-LAC-2 from Santa Cruz Biotechnology
|
||||||||
CNG-3 siRNA (h) - sc-42395 from Santa Cruz Biotechnology
|
||||||||
CNG-3 shRNA Plasmid (h) - sc-42395-SH from Santa Cruz Biotechnology
|
||||||||
CNG-3 shRNA (h) Lentiviral Particles - sc-42395-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU136121 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN1978 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1978 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR09069 from Sigma-Aldrich
|
||||||||
CNGA3 siRNA (Human) - CRH0881 from Cohesion Biosciences
|
||||||||
CNGA3 RNAi - H00001261-R01 from Novus Biologicals
|
||||||||
CNGA3 - MBS8226057 from MyBioSource
|
||||||||
shRNA set against Human CNGA3 (NM_001298.2) - SHH266177 from Creative biogene
|
||||||||
shRNA set against Human CNGA3(NM_001298.2) - SHG186473 from Creative biogene
|
||||||||
shRNA set against Human CNGA3(NM_001079878.1) - SHG186533 from Creative biogene
|
||||||||
shRNA set against Human CNGA3(NM_001298.2) - SHG186587 from Creative biogene
|
||||||||
Human CNGA3 siRNA - orb261383 from Biorbyt
|
||||||||
CNGA3 shRNA Plasmid (Human) - CHH0881 from Cohesion Biosciences
|
||||||||
CNGA3 miRNA 3'UTR clone - MiUTR1H-02266 from Creative biogene
|