Gene Symbol |
CNGA3
|
Entrez Gene |
1261
|
Alt Symbol |
ACHM2, CCNC1, CCNCa, CCNCalpha, CNCG3, CNG3
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
cyclic nucleotide gated channel alpha 3
|
Other Description |
CNG channel alpha-3|CNG-3|cone photoreceptor cGMP-gated channel alpha subunit|cone photoreceptor cGMP-gated channel subunit alpha|cyclic nucleotide-gated cation channel alpha-3|cyclic nucleotide-gated channel alpha-3
|
Swissprots |
Q6ZNA7 Q4VAP7 Q9UP64 E9PF93 Q53RD2 Q16281
|
Accessions |
AAD14208 AAY24181 EAX01911 Q16281 AF065314 AAC17440 AK131300 BAD18468 AK308149 BC096298 AAH96298 BC096299 AAH96299 BC096300 AAH96300 DQ067459 DQ067460 DQ067461 DQ426863 DQ426864 DR002103 KJ650082 AIT55915 XM_006712243 XP_006712306 XM_011510554 XP_011508856 NM_001079878 NP_001073347 NM_001298 NP_001289
|
Function |
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. {ECO:0000250, ECO:0000269|PubMed:10888875}.
|
Subcellular Location |
Membrane; Multi-pass membrane protein.
|
Tissue Specificity |
Prominently expressed in retina.
|
Top Pathways |
Olfactory transduction, cAMP signaling pathway
|