CNGA3

Gene Symbol CNGA3
Entrez Gene 1261
Alt Symbol ACHM2, CCNC1, CCNCa, CCNCalpha, CNCG3, CNG3
Species Human
Gene Type protein-coding
Description cyclic nucleotide gated channel alpha 3
Other Description CNG channel alpha-3|CNG-3|cone photoreceptor cGMP-gated channel alpha subunit|cone photoreceptor cGMP-gated channel subunit alpha|cyclic nucleotide-gated cation channel alpha-3|cyclic nucleotide-gated channel alpha-3
Swissprots Q6ZNA7 Q4VAP7 Q9UP64 E9PF93 Q53RD2 Q16281
Accessions AAD14208 AAY24181 EAX01911 Q16281 AF065314 AAC17440 AK131300 BAD18468 AK308149 BC096298 AAH96298 BC096299 AAH96299 BC096300 AAH96300 DQ067459 DQ067460 DQ067461 DQ426863 DQ426864 DR002103 KJ650082 AIT55915 XM_006712243 XP_006712306 XM_011510554 XP_011508856 NM_001079878 NP_001073347 NM_001298 NP_001289
Function Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. {ECO:0000250, ECO:0000269|PubMed:10888875}.
Subcellular Location Membrane; Multi-pass membrane protein.
Tissue Specificity Prominently expressed in retina.
Top Pathways Olfactory transduction, cAMP signaling pathway

CNGA3 overexpression lysate - LY420024 from Acris Antibodies

Category Cell Lysate
Prices $480.00
Sizes 100 µg

CNGA3 overexpression lysate - LY421573 from Acris Antibodies

Category Cell Lysate
Prices $480.00
Sizes 100 µg

CNGA3 overexpression lysate - LY429061 from Acris Antibodies

Category Cell Lysate
Prices $480.00
Sizes 100 µg

CNGA3 293 Cell Lysate - 409539 from ABBIOTEC

Category Cell Lysate
Prices $672.00
Sizes 100 µg

CNGA3 Overexpression Lysate (Native) - NBP2-08220 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg
Western Blot: CNGA3 Overexpression Lysate (Adult Normal) [NBP2-08220] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CNGA3.

CNGA3 Over-expression Lysate Product - GWB-11474A from Genway Biotech

Category Cell Lysate
Prices $756.00
Sizes 100 µg
Species Human

CNGA3 Overexpression Lysate (Native) - NBP2-09772 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg
Western Blot: CNGA3 Overexpression Lysate (Adult Normal) [NBP2-09772] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CNGA3.

CNGA3 Overexpression Lysate (Native) - NBP2-08482 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg
Western Blot: CNGA3 Overexpression Lysate (Adult Normal) [NBP2-08482] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CNGA3.

Panoply™ Human CNGA3 Knockdown Stable Cell Line - CSC-DC003359 from Creative biogene

Category Cell Line
Species Human
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