CACNA2D3

Gene Symbol CACNA2D3
Entrez Gene 55799
Alt Symbol HSA272268
Species Human
Gene Type protein-coding
Description calcium channel, voltage-dependent, alpha 2/delta subunit 3
Other Description calcium channel alpha2-delta3 subunit|calcium channel, voltage-dependent, alpha 2/delta 3 subunit|voltage-dependent calcium channel subunit alpha-2/delta-3|voltage-gated calcium channel subunit alpha-2/delta-3
Swissprots Q9NY18 Q9NY16 B2RPL6 Q8IZS8
Accessions EAW65303 EAW65304 Q8IZS8 AF516696 AAN06673 AJ272213 CAB75878 AJ272268 CAB75962 AK299718 BAG61618 AK307449 AW905454 BC137502 AAI37503 BC137505 AAI37506 BE702896 BE768691 BG206136 BG213431 BI753834 XM_005265318 XP_005265375 XM_011533946 XP_011532248 XM_011533947 XP_011532249 XM_011533948 XP_011532250 XM_011533949 XP_011532251 XM_011533950 XP_011532252 XM_011533951 XP_011532253 XM_011533952 XP_011532254 XM_011533953 XP_011532255 XM_011533954 XP_011532256 XM_011533955 XP_011532257 XR_427281 XR_427282 XR_940472 XR_940473 NM_018398 NP_060868
Function The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity). {ECO:0000250}.
Subcellular Location Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Tissue Specificity Only detected in brain. Not present in lung, testis, aorta, spleen, jejunum, ventricular muscle and kidney (at protein level). According to PubMed:11687876, it is brain- specific, while according to PubMed:11245980, it is widely expressed. {ECO:0000269|PubMed:11687876}.
Top Pathways MAPK signaling pathway, Cardiac muscle contraction, Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy

Cacna2d3 (E-15) - sc-99322 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Cacna2d3 (E-15): sc-99322. Western blot analysis of Cacna2d3 expression in non-transfected 293T: sc-117752 (A), mouse Cacna2d3 transfected 293T: sc-178349 (B) and IMR-32 (C) whole cell lysates.

Cacna2d3 (S-14) - sc-99324 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Cacna2d3 (S-14): sc-99324. Western blot analysis of Cacna2d3 expression in mouse brain tissue extract.

Cacna2d3 (N-13) - sc-99323 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Cacna2d3 (N-13): sc-99323. Western blot analysis of Cacna2d3 expression in U-251-MG (A) and HeLa (B) whole cell lysates.

Anti-CACNA2D3 antibody - ab81000 from Abcam

Prices $370.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal
IHC image of CACNA2D3 staining in Human normal cerebral cortex formalin fixed paraffin embedded tissue section, performed on a Leica Bond™ system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab81000, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-CACNA2D3 antibody - ab105099 from Abcam

Host Goat
Clonality Polyclonal

Anti-CACNA2D3 antibody - ab102939 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-CACNA2D3 antibody (ab102939) at 1/100 dilution + HepG2 cell lysate at 35 µg

Anti-CACNA2D3 / Alpha-2/Delta-3 Antibody (Internal) - LS-C94046 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-CACNA2D3 / Alpha-2/Delta-3 Antibody (C-Terminus, Biotin) - LS-C213011 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CACNA2D3 / Alpha-2/Delta-3 Antibody (C-Terminus, AP) - LS-C213008 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CACNA2D3 / Alpha-2/Delta-3 Antibody (C-Terminus, APC) - LS-C213010 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CACNA2D3 / Alpha-2/Delta-3 Antibody (C-Terminus, FITC) - LS-C213012 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CACNA2D3 / Alpha-2/Delta-3 Antibody (C-Terminus, Azide-free, HRP) - LS-C213013 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CACNA2D3 / Alpha-2/Delta-3 Antibody (C-Terminus, PE) - LS-C213014 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CACNA2D3 / Alpha-2/Delta-3 Antibody (C-Terminus) - LS-C329299 from LifeSpan Bioscience

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CACNA2D3 / Alpha-2/Delta-3 Antibody (aa1026-1053) - LS-C168259 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of CACNA2D3 Antibody in HepG2 cell line lysates (35 ug/lane). CACNA2D3 (arrow) was detected using the purified antibody.

CACNA2D3 Antibody - NBP1-20111 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CACNA2D3 Antibody - NBP2-33938 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: CACNA2D3 Antibody [NBP2-33938] - heart muscle

CACNA2D3 Antibody - NBP1-30557 from Novus Biologicals

Prices $299.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

CACNA2D3 Antibody - NBP1-46296 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Goat
Clonality Polyclonal

ANTI-CACNA2D3 (C-TERM) antibody produced in rabbit - SAB1303793 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-CACNA2D3 (C-term): <B>Cat. No. SAB1303793</B>: Western blot analysis of CACNA2D3 Antibody (C-term) in HepG2 cell line lysates (35 μg/lane).

Anti-CACNA2D3 antibody produced in rabbit - HPA030849 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-CACNA2D3: <B>Cat. No. HPA030849</B>: Immunohistochemical staining of Human skeletal muscle shows strong cytoplasmic positivity in myocytes.

CACNA2D3-Antibody-C-term - AP9739b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of CACNA2D3 Antibody (C-term) (Cat. #AP9739b) in HepG2 cell line lysates (35ug/lane). CACNA2D3 (arrow) was detected using the purified Pab.

Cav alpha 2/delta 3 antibody - GTX53537 from GeneTex

Prices $319.00
Sizes 400 μl
Host Rabbit
Clonality Polyclonal
Anti-CACNA2D3 antibody used in Western blot. GTX53537

CACNA2D3 Antibody - C-terminal region (OAAB06339) - OAAB06339 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
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