| Gene Symbol |
CACNA2D3
|
| Entrez Gene |
55799
|
| Alt Symbol |
HSA272268
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
calcium channel, voltage-dependent, alpha 2/delta subunit 3
|
| Other Description |
calcium channel alpha2-delta3 subunit|calcium channel, voltage-dependent, alpha 2/delta 3 subunit|voltage-dependent calcium channel subunit alpha-2/delta-3|voltage-gated calcium channel subunit alpha-2/delta-3
|
| Swissprots |
Q9NY18 Q9NY16 B2RPL6 Q8IZS8
|
| Accessions |
EAW65303 EAW65304 Q8IZS8 AF516696 AAN06673 AJ272213 CAB75878 AJ272268 CAB75962 AK299718 BAG61618 AK307449 AW905454 BC137502 AAI37503 BC137505 AAI37506 BE702896 BE768691 BG206136 BG213431 BI753834 XM_005265318 XP_005265375 XM_011533946 XP_011532248 XM_011533947 XP_011532249 XM_011533948 XP_011532250 XM_011533949 XP_011532251 XM_011533950 XP_011532252 XM_011533951 XP_011532253 XM_011533952 XP_011532254 XM_011533953 XP_011532255 XM_011533954 XP_011532256 XM_011533955 XP_011532257 XR_427281 XR_427282 XR_940472 XR_940473 NM_018398 NP_060868
|
| Function |
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Only detected in brain. Not present in lung, testis, aorta, spleen, jejunum, ventricular muscle and kidney (at protein level). According to PubMed:11687876, it is brain- specific, while according to PubMed:11245980, it is widely expressed. {ECO:0000269|PubMed:11687876}.
|
| Top Pathways |
MAPK signaling pathway, Cardiac muscle contraction, Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy
|
