CACNA2D3
| Gene Symbol | CACNA2D3 |
|---|---|
| Entrez Gene | 55799 |
| Alt Symbol | HSA272268 |
| Species | Human |
| Gene Type | protein-coding |
| Description | calcium channel, voltage-dependent, alpha 2/delta subunit 3 |
| Other Description | calcium channel alpha2-delta3 subunit|calcium channel, voltage-dependent, alpha 2/delta 3 subunit|voltage-dependent calcium channel subunit alpha-2/delta-3|voltage-gated calcium channel subunit alpha-2/delta-3 |
| Swissprots | Q9NY18 Q9NY16 B2RPL6 Q8IZS8 |
| Accessions | EAW65303 EAW65304 Q8IZS8 AF516696 AAN06673 AJ272213 CAB75878 AJ272268 CAB75962 AK299718 BAG61618 AK307449 AW905454 BC137502 AAI37503 BC137505 AAI37506 BE702896 BE768691 BG206136 BG213431 BI753834 XM_005265318 XP_005265375 XM_011533946 XP_011532248 XM_011533947 XP_011532249 XM_011533948 XP_011532250 XM_011533949 XP_011532251 XM_011533950 XP_011532252 XM_011533951 XP_011532253 XM_011533952 XP_011532254 XM_011533953 XP_011532255 XM_011533954 XP_011532256 XM_011533955 XP_011532257 XR_427281 XR_427282 XR_940472 XR_940473 NM_018398 NP_060868 |
| Function | The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity). {ECO:0000250}. |
| Subcellular Location | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
| Tissue Specificity | Only detected in brain. Not present in lung, testis, aorta, spleen, jejunum, ventricular muscle and kidney (at protein level). According to PubMed:11687876, it is brain- specific, while according to PubMed:11245980, it is widely expressed. {ECO:0000269|PubMed:11687876}. |
| Top Pathways | MAPK signaling pathway, Cardiac muscle contraction, Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy |
Cacna2d3 CRISPR/Cas9 KO Plasmid (h) - sc-407368 from Santa Cruz Biotechnology
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Cacna2d3 HDR Plasmid (h) - sc-407368-HDR from Santa Cruz Biotechnology
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Cacna2d3 Double Nickase Plasmid (h) - sc-407368-NIC from Santa Cruz Biotechnology
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Cacna2d3 Double Nickase Plasmid (h2) - sc-407368-NIC-2 from Santa Cruz Biotechnology
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Cacna2d3 CRISPR Activation Plasmid (h) - sc-407368-ACT from Santa Cruz Biotechnology
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Cacna2d3 CRISPR Activation Plasmid (h2) - sc-407368-ACT-2 from Santa Cruz Biotechnology
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Cacna2d3 Lentiviral Activation Particles (h) - sc-407368-LAC from Santa Cruz Biotechnology
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Cacna2d3 Lentiviral Activation Particles (h2) - sc-407368-LAC-2 from Santa Cruz Biotechnology
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Cacna2d3 siRNA (h) - sc-78007 from Santa Cruz Biotechnology
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Cacna2d3 shRNA Plasmid (h) - sc-78007-SH from Santa Cruz Biotechnology
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Cacna2d3 shRNA (h) Lentiviral Particles - sc-78007-V from Santa Cruz Biotechnology
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CACNA2D3 RNAi - H00055799-R01 from Novus Biologicals
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MISSION® esiRNA - EHU142641 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5268 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5268 from Sigma-Aldrich
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CACNA2D3 siRNA (Human) - CRJ0931 from Cohesion Biosciences
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CACNA2D3 - MBS8227503 from MyBioSource
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shRNA set against Human CACNA2D3 (NM_018398.2) - SHH253393 from Creative biogene
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shRNA set against Human CACNA2D3(NM_018398.2) - SHG131495 from Creative biogene
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Human CACNA2D3 siRNA - orb271432 from Biorbyt
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CACNA2D3 shRNA Plasmid (Human) - CHJ0931 from Cohesion Biosciences
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CACNA2D3 miRNA 3'UTR clone - MiUTR1H-01603 from Creative biogene
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