Gene Symbol | STEAP2 |
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Entrez Gene | 261729 |
Alt Symbol | IPCA1, PCANAP1, PUMPCn, STAMP1, STMP |
Species | Human |
Gene Type | protein-coding |
Description | STEAP family member 2, metalloreductase |
Other Description | SixTransMembrane Protein of Prostate 1|metalloreductase STEAP2|prostate cancer associated protein 1|prostate cancer-associated protein 1|protein up-regulated in metastatic prostate cancer|protein upregulated in metastatic prostate cancer|six transmembrane epithelial antigen of prostate 2|six transmembrane epithelial antigen of the prostate 2|six-transmembrane epithelial antigen of prostate 2 |
Swissprots | Q6YPB1 Q8IUE7 Q6UXN6 A4D1F1 G5E9C6 Q8NFT2 |
Accessions | EAL24165 EAW76889 EAW76890 EAW76891 EAW76892 EAW76893 EAW76894 Q8NFT2 AF455138 AAN04080 AF526382 AAQ08976 AK026813 AK092666 BAG52586 AK094568 AK315043 BAG37524 AY008443 AAG32147 AY008444 AAG32148 AY358267 AAQ88634 BC146341 AAI46342 BC148824 AAI48825 DQ656061 DQ656062 DR005432 XM_006715921 XP_006715984 NM_001040665 NP_001035755 NM_001040666 NP_001035756 NM_001244944 NP_001231873 NM_001244945 NP_001231874 NM_001244946 NP_001231875 NM_152999 NP_694544 |
Function | Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity). {ECO:0000250}. |
Subcellular Location | Endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:12429817}; Multi-pass membrane protein {ECO:0000269|PubMed:12429817}. |
Tissue Specificity | Expressed at high levels in prostate and at significantly lower levels in heart, brain, kidney, pancreas, and ovary. {ECO:0000269|PubMed:12095985, ECO:0000269|PubMed:12429817, ECO:0000269|PubMed:16609065}. |
Top Pathways | Mineral absorption |
Human STEAP2 full length protein - ab166097 from Abcam
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Human STEAP2 protein fragment - ab166098 from Abcam
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STEAP2 Antibody Blocking Peptide - LS-E7895 from LifeSpan Bioscience
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STEAP2 Antibody Blocking Peptide - LS-E30381 from LifeSpan Bioscience
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STEAP2 Antibody Blocking Peptide - LS-E29582 from LifeSpan Bioscience
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STEAP2 Antibody Blocking Peptide - LS-E29583 from LifeSpan Bioscience
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STEAP2 Antibody Blocking Peptide - LS-E29581 from LifeSpan Bioscience
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Recombinant Human STEAP2 Protein - H00261729-P01 from Novus Biologicals
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Recombinant Human STEAP2 Protein - H00261729-Q01 from Novus Biologicals
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STEAP2 Blocking Peptide - NBP1-76823PEP from Novus Biologicals
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STEA2-Antibody-Center-Blocking-peptide - BP5583c from Abgent, a WuXi AppTec company
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STEAP2 Peptide - GTX85435-PEP from GeneTex
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STEAP2 / STAMP1 - H00261729-P01-10 from Acris Antibodies
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STEAP2 / STAMP1 - H00261729-P01-25 from Acris Antibodies
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STEAP2 / STAMP1 - H00261729-Q01-10 from Acris Antibodies
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STEAP2 / STAMP1 - H00261729-Q01-25 from Acris Antibodies
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STEAP2 / STAMP1 Control Peptide - AP30834CP-N from Acris Antibodies
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STEAP2 Peptide - 4307P from ProSci
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STEAP2 fusion protein - Ag20418 from Proteintech Group
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STEAP2 fusion protein - ag20293 from Proteintech Group
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Recombinant Human STEAP2, His-tagged - STEAP2-3001H from Creative Biomart
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Recombinant Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) - RPH122Hu01 from Uscn Life Science Inc.
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Recombinant Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) - RPH122Hu01 from Cloud-clone
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STEAP2 Recombinant Protein Antigen - NBP1-83100PEP from Novus Biologicals
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STEAP2 Peptide, Human - M34GP15294H from Creative Peptides
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