| Gene Symbol | STEAP2 |
|---|---|
| Entrez Gene | 261729 |
| Alt Symbol | IPCA1, PCANAP1, PUMPCn, STAMP1, STMP |
| Species | Human |
| Gene Type | protein-coding |
| Description | STEAP family member 2, metalloreductase |
| Other Description | SixTransMembrane Protein of Prostate 1|metalloreductase STEAP2|prostate cancer associated protein 1|prostate cancer-associated protein 1|protein up-regulated in metastatic prostate cancer|protein upregulated in metastatic prostate cancer|six transmembrane epithelial antigen of prostate 2|six transmembrane epithelial antigen of the prostate 2|six-transmembrane epithelial antigen of prostate 2 |
| Swissprots | Q6YPB1 Q8IUE7 Q6UXN6 A4D1F1 G5E9C6 Q8NFT2 |
| Accessions | EAL24165 EAW76889 EAW76890 EAW76891 EAW76892 EAW76893 EAW76894 Q8NFT2 AF455138 AAN04080 AF526382 AAQ08976 AK026813 AK092666 BAG52586 AK094568 AK315043 BAG37524 AY008443 AAG32147 AY008444 AAG32148 AY358267 AAQ88634 BC146341 AAI46342 BC148824 AAI48825 DQ656061 DQ656062 DR005432 XM_006715921 XP_006715984 NM_001040665 NP_001035755 NM_001040666 NP_001035756 NM_001244944 NP_001231873 NM_001244945 NP_001231874 NM_001244946 NP_001231875 NM_152999 NP_694544 |
| Function | Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity). {ECO:0000250}. |
| Subcellular Location | Endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:12429817}; Multi-pass membrane protein {ECO:0000269|PubMed:12429817}. |
| Tissue Specificity | Expressed at high levels in prostate and at significantly lower levels in heart, brain, kidney, pancreas, and ovary. {ECO:0000269|PubMed:12095985, ECO:0000269|PubMed:12429817, ECO:0000269|PubMed:16609065}. |
| Top Pathways | Mineral absorption |
STEAP2 CRISPR/Cas9 KO Plasmid (h) - sc-410402 from Santa Cruz Biotechnology
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STEAP2 HDR Plasmid (h) - sc-410402-HDR from Santa Cruz Biotechnology
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STEAP2 Double Nickase Plasmid (h) - sc-410402-NIC from Santa Cruz Biotechnology
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STEAP2 Double Nickase Plasmid (h2) - sc-410402-NIC-2 from Santa Cruz Biotechnology
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STEAP2 CRISPR Activation Plasmid (h) - sc-410402-ACT from Santa Cruz Biotechnology
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STEAP2 CRISPR Activation Plasmid (h2) - sc-410402-ACT-2 from Santa Cruz Biotechnology
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STEAP2 Lentiviral Activation Particles (h) - sc-410402-LAC from Santa Cruz Biotechnology
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STEAP2 Lentiviral Activation Particles (h2) - sc-410402-LAC-2 from Santa Cruz Biotechnology
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STEAP2 siRNA (h) - sc-76587 from Santa Cruz Biotechnology
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STEAP2 shRNA Plasmid (h) - sc-76587-SH from Santa Cruz Biotechnology
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STEAP2 shRNA (h) Lentiviral Particles - sc-76587-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU027111 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20720 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20720 from Sigma-Aldrich
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STEAP2 siRNA (Human) - CRJ6827 from Cohesion Biosciences
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STEAP2 - MBS8208586 from MyBioSource
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shRNA set against Human STEAP2 (NM_152999.3) - SHH419560 from Creative biogene
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shRNA set against Human STEAP2(NM_001040665.1) - SHL033474 from Creative biogene
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shRNA set against Human STEAP2(NM_001040666.1) - SHL033528 from Creative biogene
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Human STEAP2 siRNA - orb277328 from Biorbyt
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STEAP2 shRNA Plasmid (Human) - CHJ6827 from Cohesion Biosciences
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STEAP2 miRNA 3'UTR clone - MiUTR1H-09992 from Creative biogene
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STEAP2 miRNA 3'UTR clone - MiUTR1H-09993 from Creative biogene
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