| Gene Symbol | SATB1 |
|---|---|
| Entrez Gene | 6304 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | SATB homeobox 1 |
| Other Description | DNA-binding protein SATB1|special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA)|special AT-rich sequence-binding protein 1 |
| Swissprots | Q01826 Q59EQ0 C9JTR6 B3KXF1 |
| Accessions | CAY55990 CBX55095 CDM55585 EAW64291 EAW64292 EAW64293 Q01826 AA001621 AB209761 BAD92998 AK127242 BAG54463 AU127749 BC001744 AAH01744 BE218845 BI494258 CD677701 DA938384 DB134320 DB141938 DQ891870 ABM82796 DQ895058 ABM85984 LN626687 CEH24702 M97287 AAA60304 U92993 XM_011533987 XP_011532289 XM_011533988 XP_011532290 XM_011533989 XP_011532291 XM_011533990 XP_011532292 NM_001131010 NP_001124482 NM_001195470 NP_001182399 NM_002971 NP_002962 |
| Function | Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation |
| Subcellular Location | Nucleus matrix. Nucleus, PML body. Note=Organized into a cage-like network anchoring loops of heterochromatin and tethering specialized DNA sequences. When sumoylated, localized in promyelocytic leukemia nuclear bodies (PML NBs). |
| Tissue Specificity | Expressed predominantly in thymus. {ECO:0000269|PubMed:1505028}. |