SATB1

Gene Symbol	SATB1
Entrez Gene	6304
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	SATB homeobox 1
Other Description	DNA-binding protein SATB1|special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA)|special AT-rich sequence-binding protein 1
Swissprots	Q01826 Q59EQ0 C9JTR6 B3KXF1
Accessions	CAY55990 CBX55095 CDM55585 EAW64291 EAW64292 EAW64293 Q01826 AA001621 AB209761 BAD92998 AK127242 BAG54463 AU127749 BC001744 AAH01744 BE218845 BI494258 CD677701 DA938384 DB134320 DB141938 DQ891870 ABM82796 DQ895058 ABM85984 LN626687 CEH24702 M97287 AAA60304 U92993 XM_011533987 XP_011532289 XM_011533988 XP_011532290 XM_011533989 XP_011532291 XM_011533990 XP_011532292 NM_001131010 NP_001124482 NM_001195470 NP_001182399 NM_002971 NP_002962
Function	Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation
Subcellular Location	Nucleus matrix. Nucleus, PML body. Note=Organized into a cage-like network anchoring loops of heterochromatin and tethering specialized DNA sequences. When sumoylated, localized in promyelocytic leukemia nuclear bodies (PML NBs).
Tissue Specificity	Expressed predominantly in thymus. {ECO:0000269|PubMed:1505028}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SATB1 peptide - ab111669 from Abcam Category Peptide Species Human

SATB1 Antibody Blocking Peptide - LS-E11771 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SATB1 Antibody Blocking Peptide - LS-E11772 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SATB1 Antibody Blocking Peptide - LS-E27094 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SATB1 Antibody Blocking Peptide - LS-E30511 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

SATB1 Antibody Blocking Peptide - LS-E30528 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

SATB1 Peptide - NBP1-76923PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

SATB1 Peptide - NBP1-76914PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

SATB1 blocking peptide - GTX88290-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat, Bovine

SATB1 Peptide - AC21-1916-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

SATB1 - H00006304-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SATB1 - H00006304-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SATB1 Control Peptide - AP30758CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

SATB1 Control Peptide - AP30759CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

SATB1 Peptide - 4679P from ProSci Category Peptide Species Human

SATB1 Peptide - 42-764P from ProSci Category Peptide Species Human

SATB1 Peptide - 4631P from ProSci Category Peptide Species Human

SATB1 fusion protein - Ag12278 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

SATB1 fusion protein - Ag12279 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

SATB1 fusion protein - Ag7615 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

SATB1 fusion protein - Ag7483 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human SATB1, GST-tagged - SATB1-2517H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant SATB Homeobox Protein 1 (SATB1) - RPK006Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant SATB Homeobox Protein 1 (SATB1) - RPK006Hu01 from Cloud-clone Category Protein Source E.coli Species Human

SATB1 Peptide - abx165228 from Abbexa Category Peptide Species Human, Mouse

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