SATB1

Gene Symbol SATB1
Entrez Gene 6304
Alt Symbol -
Species Human
Gene Type protein-coding
Description SATB homeobox 1
Other Description DNA-binding protein SATB1|special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA)|special AT-rich sequence-binding protein 1
Swissprots Q01826 Q59EQ0 C9JTR6 B3KXF1
Accessions CAY55990 CBX55095 CDM55585 EAW64291 EAW64292 EAW64293 Q01826 AA001621 AB209761 BAD92998 AK127242 BAG54463 AU127749 BC001744 AAH01744 BE218845 BI494258 CD677701 DA938384 DB134320 DB141938 DQ891870 ABM82796 DQ895058 ABM85984 LN626687 CEH24702 M97287 AAA60304 U92993 XM_011533987 XP_011532289 XM_011533988 XP_011532290 XM_011533989 XP_011532291 XM_011533990 XP_011532292 NM_001131010 NP_001124482 NM_001195470 NP_001182399 NM_002971 NP_002962
Function Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation
Subcellular Location Nucleus matrix. Nucleus, PML body. Note=Organized into a cage-like network anchoring loops of heterochromatin and tethering specialized DNA sequences. When sumoylated, localized in promyelocytic leukemia nuclear bodies (PML NBs).
Tissue Specificity Expressed predominantly in thymus. {ECO:0000269|PubMed:1505028}.

Phospho-SATB1 (Ser47) Antibody - 4028 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Jurkat and THP-1 cell lines using Phospho-SATB1 (Ser47) Antibody (upper) or SATB1 (L745) Antibody #3650 (lower). Antibody phospho-specificity was determined by treating cell extracts with λ phosphatase.

SATB1 (P472) Antibody - 3643 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Jurkat and THP-1 cells, and mouse thymus using SATB1 (P472) Antibody.

SATB1 (D41G7) Rabbit mAb - 8067 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D41G7
Western blot analysis of extracts from Jurkat and THP-1 cells using SATB1 (D41G7) Rabbit mAb.

SATB1 (L745) Antibody - 3650 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Jurkat and THP-1 cell lines using SATB1 (L745) Antibody.

SATB1 (E-15) - sc-5990 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SATB1 (E-15): sc-5990. Western blot analysis of SATB1 expression in BJAB (A), C32 (B) and SK-BR-3 (C) nuclear extracts.

SATB1 (H-70) - sc-28676 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SATB1 (H-70): sc-28676. Western blot analysis of SATB1 expression in non-transfected: sc-117752 (A) and human SATB1 transfected: sc-172050 (B) 293T whole cell lysates.

SATB1 (N-14) - sc-5989 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SATB1 (N-14): sc-5989. Western blot analysis of SATB1 expression in mouse thymus extract.

Anti-SATB1 antibody - ab49061 from Abcam

Prices $400.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-SATB1 antibody (ab49061) at 1.25 µg/mlLane 2 : Anti-SATB1 antibody (ab49061) at 2.5 µg/mlLane 3 : Anti-SATB1 antibody (ab49061) at 5 µg/mlLane 1 : Cell lysate prepared from human Jurkat cellsLane 2 : Cell lysate prepared from human Jurkat cellsLane 3 : Cell lysate prepared from human Jurkat cellsLysates/proteins at 25 µg per lane.

Anti-SATB1 antibody - ab70004 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-SATB1 antibody (ab70004) at 1 µg/mlLane 2 : Anti-SATB1 antibody (ab70004) at 2 µg/mlLane 1 : SK-N-SH cell lysateLane 2 : SK-N-SH cell lysateLysates/proteins at 15 µg per lane.

Anti-SATB1 antibody - ab189372 from Abcam

Prices $376.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human thymus tissue labeling SATB1 with ab189372 at 3.75 µg/ml.

Anti-SATB1 antibody - ab106941 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-SATB1 antibody (ab106941) at 0.3 µg/ml + MOLT4 cell lysate (in RIPA buffer) at 35 µgdeveloped using the ECL technique

Anti-SATB1 antibody - ab101085 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-SATB1 antibody (ab101085) at 1 µg/ml + Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate at 10 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-SATB1 antibody - ab172261 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-SATB1 antibody (ab172261) at 1 µg/mlLane 1 : SATB1 transfected 293T cell line lysateLane 2 : Non-transfected 293T cell line lysateBlocking peptides at 15 µl per lane.developed using the ECL technique

Anti-SATB1 antibody [6C6] - ab113933 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 6C6
Immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SATB1 using ab113933 at a dilution of 1/100.

Anti-SATB1 antibody [EPR3895] - ab92307 from Abcam

Prices $403.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3895
All lanes : Anti-SATB1 antibody [EPR3895] (ab92307) at 1/1000 dilution (unpurified)Lane 1 : Jurkat cell lysateLane 2 : Mouse thymus tissue lysateLysates/proteins at 10 µg per lane.SecondaryHRP-conjugated goat anti-rabbit IgG at 1/2000 dilution

Anti-SATB1 antibody [EPR3951] - ab109122 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3951
All lanes : Anti-SATB1 antibody [EPR3951] (ab109122) at 1/1000 dilutionLane 1 : Jurkat cell lysatesLane 2 : Fetal thymus lysatesLane 3 : Mouse thymus lysatesLysates/proteins at 10 µg per lane.SecondaryHRP labelled Goat anti-Rabbit at 1/2000 dilution

Anti-SATB1 antibody - C-terminal - ab189847 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence analysis of A549 cells using ab189847. Blue DAPI for nuclear staining.

Anti-SATB1 Antibody (aa611-660) - LS-C30243 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
A: Marker, B: Transfected 293T Cell Lysate

Anti-SATB1 Antibody (C-Terminus) - LS-C31409 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
A: Marker, B: Jurkat Cell Lysate

Anti-SATB1 Antibody (C-Terminus) - LS-C126247 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-SATB1 Antibody - LS-C132017 from LifeSpan Bioscience

Prices $355.00
Sizes 40 µl
Host Rabbit
Clonality Polyclonal

Anti-SATB1 Antibody (C-Terminus) - LS-C115970 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SATB1 antibody LS-C115970 Western blot of Transfected 293T cell lysate.

Anti-SATB1 Antibody - LS-C341875 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SATB1 Antibody (Internal, clone EPR3951) IHC-plus™ - LS-B7514 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3951
Anti-SATB1 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7514 dilution 1:50.

Anti-SATB1 Antibody (clone 11H4) - LS-C114620 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 11H4
IHC of paraffin-embedded Ovary tissue using anti-SATB1 mouse monoclonal antibody. (Dilution 1:50).
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