NPC1

Gene Symbol	NPC1
Entrez Gene	4864
Alt Symbol	NPC
Species	Human
Gene Type	protein-coding
Description	Niemann-Pick disease, type C1
Other Description	Niemann-Pick C1 protein
Swissprots	O15118 Q9P130 B4DET3
Accessions	AAD48006 AAK25791 EAX01158 O15118 AB209048 BAD92285 AB971140 BAQ08368 AF002020 AAB63982 AI242474 AK293779 BAG57194 AK295715 BAG58559 AK308491 BC063302 AAH63302 BP217319 CA438246 DR159421 XM_005258277 XP_005258334 XM_005258278 XP_005258335 XM_005258279 XP_005258336 XM_006722479 XP_006722542 XM_011526015 XP_011524317 NM_000271 NP_000262
Function	Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting membrane of late endosomes/ lysosomes to the ER and plasma membrane by an unknown mechanism. Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of ne
Subcellular Location	Late endosome membrane {ECO:0000269|PubMed:17897319}; Multi-pass membrane protein {ECO:0000269|PubMed:17897319}. Lysosome membrane {ECO:0000269|PubMed:17897319}; Multi-pass membrane protein {ECO:0000269|PubMed:17897319}.
Top Pathways	Lysosome

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human NPC ELISA Kit - HN0103 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine NPC ELISA Kit - AN0103 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Niemann Pick C1 protein (NPC1), ELISA Kit - MBS7241955 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 pg/mL.

Niemann-Pick C1 protein (NPC1), ELISA Kit - MBS7242282 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Niemann-Pick C1 protein (NPC1), ELISA Kit - MBS7224175 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Niemann-Pick C1 protein (NPC1), ELISA Kit - MBS7233193 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Niemann-Pick C1 protein (NPC1), ELISA Kit - MBS7221163 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Niemann-Pick C1 protein (NPC1), ELISA Kit - MBS7224759 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Niemann-Pick C1 protein (NPC1), ELISA Kit - MBS7244736 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Niemann-Pick C1 protein (NPC1), ELISA Kit - MBS7222996 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Niemann-Pick C1 protein (NPC1), ELISA Kit - MBS7211224 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Niemann-Pick C1 protein (NPC1), ELISA Kit - MBS7216102 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Niemann-Pick C1 protein (NPC1), ELISA Kit - MBS7201260 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Niemann-Pick disease, type C1, ELISA Kit - MBS9320668 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 10 pg/ml. Range 62.5 pg/ml - 2000 pg/ml.

Human NPC ELISA Kit - E025854 from Biobool Category ELISA Kit

Human NPC ELISA Kit - EHN0103 from ABclonal Category ELISA Kit Prices $495.00 Sizes 96 t

Niemann Pick C1 Protein (NPC1), ELISA Kit - MBS9359475 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Niemann Pick C1 Protein (NPC1), ELISA Kit - MBS9349616 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Niemann Pick C1 Protein (NPC1), ELISA Kit - MBS9361024 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Niemann Pick C1 Protein (NPC1), ELISA Kit - MBS9369495 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Niemann Pick C1 Protein (NPC1), ELISA Kit - MBS9349798 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Niemann Pick C1 Protein (NPC1), ELISA Kit - MBS9353063 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Niemann Pick C1 Protein (NPC1), ELISA Kit - MBS9348058 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Niemann Pick C1 Protein (NPC1), ELISA Kit - MBS9352664 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Niemann Pick C1 Protein (NPC1), ELISA Kit - MBS9351365 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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