NPC1

Gene Symbol NPC1
Entrez Gene 4864
Alt Symbol NPC
Species Human
Gene Type protein-coding
Description Niemann-Pick disease, type C1
Other Description Niemann-Pick C1 protein
Swissprots O15118 Q9P130 B4DET3
Accessions AAD48006 AAK25791 EAX01158 O15118 AB209048 BAD92285 AB971140 BAQ08368 AF002020 AAB63982 AI242474 AK293779 BAG57194 AK295715 BAG58559 AK308491 BC063302 AAH63302 BP217319 CA438246 DR159421 XM_005258277 XP_005258334 XM_005258278 XP_005258335 XM_005258279 XP_005258336 XM_006722479 XP_006722542 XM_011526015 XP_011524317 NM_000271 NP_000262
Function Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting membrane of late endosomes/ lysosomes to the ER and plasma membrane by an unknown mechanism. Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of ne
Subcellular Location Late endosome membrane {ECO:0000269|PubMed:17897319}; Multi-pass membrane protein {ECO:0000269|PubMed:17897319}. Lysosome membrane {ECO:0000269|PubMed:17897319}; Multi-pass membrane protein {ECO:0000269|PubMed:17897319}.
Top Pathways Lysosome

NPC1 CRISPR/Cas9 KO Plasmid (h) - sc-403252 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NPC1 HDR Plasmid (h) - sc-403252-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NPC1 Double Nickase Plasmid (h) - sc-403252-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NPC1 Double Nickase Plasmid (h2) - sc-403252-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NPC1 CRISPR Activation Plasmid (h) - sc-403252-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NPC1 CRISPR Activation Plasmid (h2) - sc-403252-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NPC1 Lentiviral Activation Particles (h) - sc-403252-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NPC1 Lentiviral Activation Particles (h2) - sc-403252-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NPC1 siRNA (h) - sc-41588 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NPC1 shRNA Plasmid (h) - sc-41588-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NPC1 shRNA (h) Lentiviral Particles - sc-41588-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU136281 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15442 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15442 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06280 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr06280

NPC1 siRNA (Human) - CRH3235 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human NPC1 (NM_000271.4) - SHH354092 from Creative biogene

Category siRNA
Species Reactivities Human

NPC1 shRNA Plasmid (Human) - CHH3235 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

NPC1 miRNA 3'UTR clone - MiUTR3H-09352 from Creative biogene

Species Reactivities Human
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