ATG5

Gene Symbol	ATG5
Entrez Gene	9474
Alt Symbol	APG5, APG5-LIKE, APG5L, ASP, hAPG5
Species	Human
Gene Type	protein-coding
Description	autophagy related 5
Other Description	ATG5 autophagy related 5 homolog|apoptosis-specific protein|autophagy protein 5
Swissprots	Q9H1Y0 Q9HCZ7 Q5JVR2 Q9H2B8 O60875 Q68DI4
Accessions	EAW48414 EAW48415 EAW48416 EAW48417 EAW48418 Q9H1Y0 AF293841 AAG44955 AK001899 BAG50990 AK299577 BAH13072 AK315800 BC002699 AAH02699 BC093011 AAH93011 BM831472 BP297166 BX537904 CAD97890 CR749386 CAH18236 EU283338 EU283339 ABX79918 HQ447996 ADQ32477 HY168998 JQ918353 AGC52701 JQ918354 AGC52702 JQ924061 AGC52703 Y11588 CAA72327 XM_011536263 XP_011534565 NM_001286106 NP_001273035 NM_001286107 NP_001273036 NM_001286108 NP_001273037 NM_001286111 NP_001273040 NM_004849 NP_004840 NR_104402 NR_104403
Function	Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. The ATG12- ATG5 conjugate also negatively regulates the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Also plays a role in translation or delivery of incoming viral RNA to the translation apparatus. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in
Subcellular Location	Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein. Note=Colocalizes with nonmuscle actin. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (By similarity). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. {ECO:0000250}.
Tissue Specificity	Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells.
Top Pathways	RIG-I-like receptor signaling pathway, Regulation of autophagy

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human APG5 / ATG5 ELISA Kit (Sandwich ELISA) - LS-F10895 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 ng/ml Range 0.312-20 ng/ml

Autophagy protein 5 (ATG5), Human, ELISA Kit - E01A1750 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Autophagy protein 5, ATG5, Human, ELISA Kit - E15032h from ARP American Research Products Category ELISA Kit Prices $736.00 Sizes 96 t Range 0.312-20 ng/mL

Autophagy protein 5, ATG5, ELISA Kit - MBS2602759 from MyBioSource Category ELISA Kit Prices $275.00, $420.00, $1,615.00, $2,880.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/ml. Range 50 ng/ml-0.78 ng/ml

ELISA Kit for Autophagy Related Protein 5 (ATG5) - SEL221Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.29ng/mL. Range 0.781-50ng/mL The standard curve concentrations used for the ELISA’s were 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.125ng/mL, 1.563ng/mL, 0.781ng/mL

Pig APG5 / ATG5 ELISA Kit (Custom ELISA) - LS-F17685 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.312-20 ng/ml

Rat APG5 / ATG5 ELISA Kit (Custom ELISA) - LS-F17686 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.312-20 ng/ml

Bovine APG5 / ATG5 ELISA Kit (Custom ELISA) - LS-F17684 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.312-20 ng/ml

Mouse APG5 / ATG5 ELISA Kit (Custom ELISA) - LS-F17687 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.312-20 ng/ml

Human APG5 / ATG5 ELISA Kit (Sandwich ELISA) - LS-F25581 from LifeSpan Bioscience Category ELISA Kit Prices $850.00 Sizes 1 plate Sensitivity 0.33 ng/ml Range 0.312-20 ng/ml

ATG5 - EKH3458 from Nordic BioSite Sensitivity 0.188ng/ml Range 0.312-20ng/ml

ATG5 ELISA Kit (Human) : 96 Wells (OKEH02452) - OKEH02452 from Aviva Systems Biology Category ELISA Kit Prices $480.00 Sizes 96 wells Sensitivity < 0.12 ng/mL Range 0.312 - 20 ng/mL

Human ATG5 ELISA Kit - E004249 from Biobool Category ELISA Kit Sensitivity 0.1 ng/mL.

Human Autophagy protein 5 ELISA Kit - EK3588 from Signalway Antibody Category ELISA Kit Prices $739.00 Sizes 1x96t Sensitivity less than 0.12ng/ml Range 0.312-20 ng/mL

anti-ATG5 antibody - ARG54822 from Arigo Biolaboratories Category ELISA Kit

anti-ATG5 antibody - ARG54821 from Arigo Biolaboratories Category ELISA Kit

Autophagy protein 5, ELISA Kit - MBS2882915 from MyBioSource Category ELISA Kit Prices $430.00, $570.00, $2,515.00, $4,520.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.312-20 ng/mL

Autophagy protein 5, ELISA Kit - MBS9427422 from MyBioSource Category ELISA Kit Prices $670.00 Sizes 96 tests Sensitivity Less than 0.12ng/mL Range 0.312-20 ng/mL

Human APG5 / ATG5 ELISA Kit (Sandwich ELISA) - LS-F35854 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.188 Range 0.312-20 ng/ml

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