ATG5

Gene Symbol	ATG5
Entrez Gene	9474
Alt Symbol	APG5, APG5-LIKE, APG5L, ASP, hAPG5
Species	Human
Gene Type	protein-coding
Description	autophagy related 5
Other Description	ATG5 autophagy related 5 homolog|apoptosis-specific protein|autophagy protein 5
Swissprots	Q9H1Y0 Q9HCZ7 Q5JVR2 Q9H2B8 O60875 Q68DI4
Accessions	EAW48414 EAW48415 EAW48416 EAW48417 EAW48418 Q9H1Y0 AF293841 AAG44955 AK001899 BAG50990 AK299577 BAH13072 AK315800 BC002699 AAH02699 BC093011 AAH93011 BM831472 BP297166 BX537904 CAD97890 CR749386 CAH18236 EU283338 EU283339 ABX79918 HQ447996 ADQ32477 HY168998 JQ918353 AGC52701 JQ918354 AGC52702 JQ924061 AGC52703 Y11588 CAA72327 XM_011536263 XP_011534565 NM_001286106 NP_001273035 NM_001286107 NP_001273036 NM_001286108 NP_001273037 NM_001286111 NP_001273040 NM_004849 NP_004840 NR_104402 NR_104403
Function	Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. The ATG12- ATG5 conjugate also negatively regulates the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Also plays a role in translation or delivery of incoming viral RNA to the translation apparatus. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in
Subcellular Location	Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein. Note=Colocalizes with nonmuscle actin. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (By similarity). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. {ECO:0000250}.
Tissue Specificity	Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells.
Top Pathways	RIG-I-like receptor signaling pathway, Regulation of autophagy

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence® Atg5 siRNA I - 6345 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

APG5 CRISPR/Cas9 KO Plasmid (h) - sc-416847 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

APG5 HDR Plasmid (h) - sc-416847-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

APG5 Double Nickase Plasmid (h) - sc-416847-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

APG5 Double Nickase Plasmid (h2) - sc-416847-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

APG5 CRISPR Activation Plasmid (h) - sc-416847-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

APG5 CRISPR Activation Plasmid (h2) - sc-416847-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

APG5 Lentiviral Activation Particles (h) - sc-416847-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

APG5 Lentiviral Activation Particles (h2) - sc-416847-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

APG5 siRNA (h) - sc-41445 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

APG5 shRNA Plasmid (h) - sc-41445-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

APG5 shRNA (h) Lentiviral Particles - sc-41445-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU085781 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1217 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1217 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR13219 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr13219

ATG5 siRNA (Human) - CRH6289 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

ATG5 RNAi - H00009474-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

ATG5 - MBS8203825 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human ATG5 (NM_004849.2) - SHH242162 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human ATG5(NM_004849.2) - SHG080263 from Creative biogene Category siRNA Species Reactivities Human

Human ATG5 siRNA - orb266791 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

ATG5 shRNA Plasmid (Human) - CHH6289 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

ATG5 miRNA 3'UTR clone - MiUTR1H-00665 from Creative biogene Species Reactivities Human

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