| Gene Symbol | ATG5 |
|---|---|
| Entrez Gene | 9474 |
| Alt Symbol | APG5, APG5-LIKE, APG5L, ASP, hAPG5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | autophagy related 5 |
| Other Description | ATG5 autophagy related 5 homolog|apoptosis-specific protein|autophagy protein 5 |
| Swissprots | Q9H1Y0 Q9HCZ7 Q5JVR2 Q9H2B8 O60875 Q68DI4 |
| Accessions | EAW48414 EAW48415 EAW48416 EAW48417 EAW48418 Q9H1Y0 AF293841 AAG44955 AK001899 BAG50990 AK299577 BAH13072 AK315800 BC002699 AAH02699 BC093011 AAH93011 BM831472 BP297166 BX537904 CAD97890 CR749386 CAH18236 EU283338 EU283339 ABX79918 HQ447996 ADQ32477 HY168998 JQ918353 AGC52701 JQ918354 AGC52702 JQ924061 AGC52703 Y11588 CAA72327 XM_011536263 XP_011534565 NM_001286106 NP_001273035 NM_001286107 NP_001273036 NM_001286108 NP_001273037 NM_001286111 NP_001273040 NM_004849 NP_004840 NR_104402 NR_104403 |
| Function | Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. The ATG12- ATG5 conjugate also negatively regulates the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Also plays a role in translation or delivery of incoming viral RNA to the translation apparatus. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in |
| Subcellular Location | Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein. Note=Colocalizes with nonmuscle actin. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (By similarity). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. {ECO:0000250}. |
| Tissue Specificity | Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells. |
| Top Pathways | RIG-I-like receptor signaling pathway, Regulation of autophagy |