| Gene Symbol |
LRRC8C
|
| Entrez Gene |
84230
|
| Alt Symbol |
AD158, FAD158
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
leucine rich repeat containing 8 family, member C
|
| Other Description |
factor for adipocyte differentiation 158|hypothetical protein AD158|leucine rich repeat containing 8C|leucine-rich repeat-containing protein 8C|volume-regulated anion channel subunit LRRC8C
|
| Swissprots |
Q8TDW0 B3KXS9 Q29RV6 Q9H075
|
| Accessions |
CBX47551 EAW73134 Q8TDW0 AB081509 BAB86303 AI014679 AK094804 AK127881 BAG54591 AL136919 CAB66853 AL699030 BC036122 AAH36122 BC103929 BC113973 AAI13974 HG492250 XM_006710960 XP_006711023 XM_011542282 XP_011540584 XM_011542283 XP_011540585 XM_011542284 XP_011540586 XM_011542285 XP_011540587 NM_032270 NP_115646
|
| Function |
Component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8C constitutes a pore-forming subunit or whether it is closely associated with the pore. May play a role in adipogenesis (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Expressed at highest levels in skeletal muscle, and at moderate levels in heart, lung and peripheral blood leukocytes. {ECO:0000269|PubMed:15564382}.
|