LRRC8C

Gene Symbol LRRC8C
Entrez Gene 84230
Alt Symbol AD158, FAD158
Species Human
Gene Type protein-coding
Description leucine rich repeat containing 8 family, member C
Other Description factor for adipocyte differentiation 158|hypothetical protein AD158|leucine rich repeat containing 8C|leucine-rich repeat-containing protein 8C|volume-regulated anion channel subunit LRRC8C
Swissprots Q8TDW0 B3KXS9 Q29RV6 Q9H075
Accessions CBX47551 EAW73134 Q8TDW0 AB081509 BAB86303 AI014679 AK094804 AK127881 BAG54591 AL136919 CAB66853 AL699030 BC036122 AAH36122 BC103929 BC113973 AAI13974 HG492250 XM_006710960 XP_006711023 XM_011542282 XP_011540584 XM_011542283 XP_011540585 XM_011542284 XP_011540586 XM_011542285 XP_011540587 NM_032270 NP_115646
Function Component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8C constitutes a pore-forming subunit or whether it is closely associated with the pore. May play a role in adipogenesis (By similarity). {ECO:0000250}.
Subcellular Location Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Tissue Specificity Expressed at highest levels in skeletal muscle, and at moderate levels in heart, lung and peripheral blood leukocytes. {ECO:0000269|PubMed:15564382}.

LRRC8C CRISPR/Cas9 KO Plasmid (h) - sc-413584 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRRC8C HDR Plasmid (h) - sc-413584-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRRC8C Double Nickase Plasmid (h) - sc-413584-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRRC8C Double Nickase Plasmid (h2) - sc-413584-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRRC8C CRISPR Activation Plasmid (h) - sc-413584-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRRC8C CRISPR Activation Plasmid (h2) - sc-413584-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRRC8C Lentiviral Activation Particles (h) - sc-413584-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRRC8C Lentiviral Activation Particles (h2) - sc-413584-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRRC8C siRNA (h) - sc-88598 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LRRC8C shRNA Plasmid (h) - sc-88598-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LRRC8C shRNA (h) Lentiviral Particles - sc-88598-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU008991 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN12766 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12766 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

LRRC8C siRNA (Human) - CRJ3365 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human LRRC8C (NM_032270.4) - SHH334867 from Creative biogene

Category siRNA
Species Reactivities Human

LRRC8C shRNA Plasmid (Human) - CHJ3365 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

LRRC8C miRNA 3'UTR clone - MiUTR4H-TG05156 from Creative biogene

Species Reactivities Human
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