| Gene Symbol | STX4 |
|---|---|
| Entrez Gene | 6810 |
| Alt Symbol | STX4A, p35-2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | syntaxin 4 |
| Other Description | renal carcinoma antigen NY-REN-31|syntaxin 4A (placental)|syntaxin-4 |
| Swissprots | Q6FHE8 A8MXY0 Q15525 Q12846 |
| Accessions | EAW52175 EAW52176 EAW52177 Q12846 AF026007 AAB88810 AF318489 AAG40313 AJ000541 CAA04174 AK091833 BAG52424 AK296652 BAH12411 AK315716 BAG38075 BC002436 AAH02436 BI755734 BQ775670 BT007326 AAP35990 CR541806 CAG46605 U07158 AAA20967 X85784 CAA59769 XM_005255521 XP_005255578 XM_011545925 XP_011544227 NM_001272095 NP_001259024 NM_001272096 NP_001259025 NM_004604 NP_004595 |
| Function | Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones. {ECO:0000250}. |
| Subcellular Location | Cell membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. |
| Tissue Specificity | Expressed in neutrophils and neutrophil- differentiated HL-60 cells. Expression in neutrophils increases with differentiation. {ECO:0000269|PubMed:10080545}. |
| Top Pathways | Vasopressin-regulated water reabsorption, SNARE interactions in vesicular transport |