Gene Symbol | STX4 |
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Entrez Gene | 6810 |
Alt Symbol | STX4A, p35-2 |
Species | Human |
Gene Type | protein-coding |
Description | syntaxin 4 |
Other Description | renal carcinoma antigen NY-REN-31|syntaxin 4A (placental)|syntaxin-4 |
Swissprots | Q6FHE8 A8MXY0 Q15525 Q12846 |
Accessions | EAW52175 EAW52176 EAW52177 Q12846 AF026007 AAB88810 AF318489 AAG40313 AJ000541 CAA04174 AK091833 BAG52424 AK296652 BAH12411 AK315716 BAG38075 BC002436 AAH02436 BI755734 BQ775670 BT007326 AAP35990 CR541806 CAG46605 U07158 AAA20967 X85784 CAA59769 XM_005255521 XP_005255578 XM_011545925 XP_011544227 NM_001272095 NP_001259024 NM_001272096 NP_001259025 NM_004604 NP_004595 |
Function | Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones. {ECO:0000250}. |
Subcellular Location | Cell membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. |
Tissue Specificity | Expressed in neutrophils and neutrophil- differentiated HL-60 cells. Expression in neutrophils increases with differentiation. {ECO:0000269|PubMed:10080545}. |
Top Pathways | Vasopressin-regulated water reabsorption, SNARE interactions in vesicular transport |
Syntaxin 4 CRISPR/Cas9 KO Plasmid (h) - sc-402879 from Santa Cruz Biotechnology
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Syntaxin 4 HDR Plasmid (h) - sc-402879-HDR from Santa Cruz Biotechnology
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Syntaxin 4 Double Nickase Plasmid (h) - sc-402879-NIC from Santa Cruz Biotechnology
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Syntaxin 4 Double Nickase Plasmid (h2) - sc-402879-NIC-2 from Santa Cruz Biotechnology
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Syntaxin 4 CRISPR Activation Plasmid (h) - sc-402879-ACT from Santa Cruz Biotechnology
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Syntaxin 4 CRISPR Activation Plasmid (h2) - sc-402879-ACT-2 from Santa Cruz Biotechnology
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Syntaxin 4 Lentiviral Activation Particles (h) - sc-402879-LAC from Santa Cruz Biotechnology
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Syntaxin 4 Lentiviral Activation Particles (h2) - sc-402879-LAC-2 from Santa Cruz Biotechnology
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Syntaxin 4 siRNA (h) - sc-36590 from Santa Cruz Biotechnology
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Syntaxin 4 shRNA Plasmid (h) - sc-36590-SH from Santa Cruz Biotechnology
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Syntaxin 4 shRNA (h) Lentiviral Particles - sc-36590-V from Santa Cruz Biotechnology
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Syntaxin 4 RNAi - H00006810-R01 from Novus Biologicals
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MISSION® esiRNA - EHU033151 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20786 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20786 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02749 from Sigma-Aldrich
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STX4 siRNA (Human) - CRH4655 from Cohesion Biosciences
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STX4 - MBS8227388 from MyBioSource
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shRNA set against Human STX4 (NM_004604.3) - SHH420364 from Creative biogene
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shRNA set against Human STX4(NM_004604.3) - SHL045884 from Creative biogene
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Human STX4 siRNA - orb265157 from Biorbyt
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STX4 shRNA Plasmid (Human) - CHH4655 from Cohesion Biosciences
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STX4 miRNA 3'UTR clone - MiUTR1H-10037 from Creative biogene
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