| Gene Symbol |
HEYL
|
| Entrez Gene |
26508
|
| Alt Symbol |
HESR3, HEY3, HRT3, bHLHb33
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
hes-related family bHLH transcription factor with YRPW motif-like
|
| Other Description |
HEY-like protein|HRT-3|class B basic helix-loop-helix protein 33|hHRT3|hHeyL|hairy-related transcription factor 3|hairy/enhancer-of-split related with YRPW motif 3|hairy/enhancer-of-split related with YRPW motif-like protein
|
| Swissprots |
Q5TG99 Q9NQ87
|
| Accessions |
EAX07260 Q9NQ87 AF311885 AAG31158 AJ272215 CAB75716 AK300463 BAG62182 AL541019 BC006087 AAH06087 BM682076 EU446871 ABZ92400 XM_005270745 XP_005270802 NM_014571 NP_055386
|
| Function |
Downstream effector of Notch signaling which may be required for cardiovascular development (By similarity). Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (By similarity). Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. {ECO:0000250, ECO:0000269|PubMed:15485867}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00380, ECO:0000255|PROSITE-ProRule:PRU00981}.
|
![Western Blot: Hey L Overexpression Lysate (Adult Normal) [NBL1-11523] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Hey L.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5319_Hey%2520L%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11523-img0002.jpg)