| Gene Symbol |
ADIRF
|
| Entrez Gene |
10974
|
| Alt Symbol |
AFRO, APM2, C10orf116, apM-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
adipogenesis regulatory factor
|
| Other Description |
adipogenesis factor rich in obesity|adipose most abundant gene transcript 2 protein|adipose specific 2|adipose-specific protein 2
|
| Swissprots |
Q15847
|
| Accessions |
EAW80313 Q15847 AI401530 AK312031 BAG34968 BC004471 AAH04471 BM789611 BM850559 CD722742 D45370 BAA08226 NM_006829 NP_006820
|
| Function |
Plays a role in fat cell development; promotes adipogenic differentiation and stimulates transcription initiation of master adipogenesis factors like PPARG and CEBPA at early stages of preadipocyte differentiation. Its overexpression confers resistance to the anticancer chemotherapeutic drug cisplatin. {ECO:0000269|PubMed:19444912, ECO:0000269|PubMed:23239344}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:23239344}.
|
| Tissue Specificity |
Expressed in adipose tissue (at protein level). Highly expressed in omental and subcutaneous adipose tissues. Expressed in heart, cornea, liver, kidney and spleen. {ECO:0000269|PubMed:23239344, ECO:0000269|Ref.4}.
|
![Western Blot: APM2 Overexpression Lysate (Adult Normal) [NBL1-08071] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for APM2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7251_APM2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-08071-img0002.jpg)