Gene Symbol | ADIRF |
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Entrez Gene | 10974 |
Alt Symbol | AFRO, APM2, C10orf116, apM-2 |
Species | Human |
Gene Type | protein-coding |
Description | adipogenesis regulatory factor |
Other Description | adipogenesis factor rich in obesity|adipose most abundant gene transcript 2 protein|adipose specific 2|adipose-specific protein 2 |
Swissprots | Q15847 |
Accessions | EAW80313 Q15847 AI401530 AK312031 BAG34968 BC004471 AAH04471 BM789611 BM850559 CD722742 D45370 BAA08226 NM_006829 NP_006820 |
Function | Plays a role in fat cell development; promotes adipogenic differentiation and stimulates transcription initiation of master adipogenesis factors like PPARG and CEBPA at early stages of preadipocyte differentiation. Its overexpression confers resistance to the anticancer chemotherapeutic drug cisplatin. {ECO:0000269|PubMed:19444912, ECO:0000269|PubMed:23239344}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:23239344}. |
Tissue Specificity | Expressed in adipose tissue (at protein level). Highly expressed in omental and subcutaneous adipose tissues. Expressed in heart, cornea, liver, kidney and spleen. {ECO:0000269|PubMed:23239344, ECO:0000269|Ref.4}. |
APM2 CRISPR/Cas9 KO Plasmid (h) - sc-416927 from Santa Cruz Biotechnology
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APM2 HDR Plasmid (h) - sc-416927-HDR from Santa Cruz Biotechnology
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APM2 Double Nickase Plasmid (h) - sc-416927-NIC from Santa Cruz Biotechnology
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APM2 Double Nickase Plasmid (h2) - sc-416927-NIC-2 from Santa Cruz Biotechnology
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APM2 CRISPR Activation Plasmid (h) - sc-416927-ACT from Santa Cruz Biotechnology
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APM2 CRISPR Activation Plasmid (h2) - sc-416927-ACT-2 from Santa Cruz Biotechnology
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APM2 Lentiviral Activation Particles (h) - sc-416927-LAC from Santa Cruz Biotechnology
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APM2 Lentiviral Activation Particles (h2) - sc-416927-LAC-2 from Santa Cruz Biotechnology
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APM2 siRNA (h) - sc-90461 from Santa Cruz Biotechnology
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APM2 shRNA Plasmid (h) - sc-90461-SH from Santa Cruz Biotechnology
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APM2 shRNA (h) Lentiviral Particles - sc-90461-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU118881 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN4135 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4135 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02520 from Sigma-Aldrich
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ADIRF siRNA (Human) - CRH7493 from Cohesion Biosciences
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ADIRF - MBS8217887 from MyBioSource
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shRNA set against Human C10orf116(NM_006829.2) - SHG108953 from Creative biogene
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ADIRF shRNA Plasmid (Human) - CHH7493 from Cohesion Biosciences
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C10ORF116 miRNA 3'UTR clone - MiUTR1H-00992 from Creative biogene
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