| Gene Symbol |
DEFB103B
|
| Entrez Gene |
55894
|
| Alt Symbol |
BD-3, DEFB-3, DEFB103, DEFB3, HBD-3, HBD3, HBP-3, HBP3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
defensin, beta 103B
|
| Other Description |
beta-defensin 103|beta-defensin 3|defensin, beta 103|defensin-like protein
|
| Swissprots |
Q9NPF6 P81534 Q8NFG6
|
| Accessions |
P81534 AB037972 BAB40572 AF217245 AAF73853 AF295370 AAG02237 AF301470 AAG22030 AF516673 AAM62424 AJ237673 CAC03097 AY785153 AAV41025 EU918408 ACK99045 NM_018661 NP_061131
|
| Function |
Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed. {ECO:0000269|PubMed:11085990}.
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Highly expressed in skin and tonsils, and to a lesser extent in trachea, uterus, kidney, thymus, adenoid, pharynx and tongue. Low expression in salivary gland, bone marrow, colon, stomach, polyp and larynx. No expression in small intestine. {ECO:0000269|PubMed:11085990}.
|