Gene Symbol | CALCOCO2 |
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Entrez Gene | 10241 |
Alt Symbol | NDP52 |
Species | Human |
Gene Type | protein-coding |
Description | calcium binding and coiled-coil domain 2 |
Other Description | antigen nuclear dot 52 kDa protein|calcium-binding and coiled-coil domain-containing protein 2|nuclear domain 10 protein 52|nuclear domain 10 protein NDP52|nuclear dot protein 52 |
Swissprots | E9PBE5 Q13137 Q6IBN9 B4DDT4 B4E0C0 Q53HB5 Q53FQ5 B4DP36 B2RBT0 E7ENK0 Q9BTF7 E7ETP5 B4DDC4 |
Accessions | EAW94707 EAW94708 Q13137 AF085965 AK222666 BAD96386 AK223227 BAD96947 AK293137 BAG56685 AK293329 BAG56845 AK298177 BAG60448 AK303313 BAG64382 AK304024 BAG64939 AK310648 AK314796 BAG37327 AL042638 AL046722 BC004130 AAH04130 BC015893 AAH15893 BE315542 BG773301 BU620013 CR456763 CAG33044 HQ448259 ADQ32739 JF432510 ADZ15727 U22897 AAA75297 XM_011524181 XP_011522483 NM_001261390 NP_001248319 NM_001261391 NP_001248320 NM_001261393 NP_001248322 NM_001261395 NP_001248324 NM_005831 NP_005822 |
Function | May play a role in ruffle formation and actin cytoskeleton organization. Seems to negatively regulate constitutive secretion. {ECO:0000269|PubMed:17635994}. |
Subcellular Location | Cytoplasm, perinuclear region. Golgi apparatus. Cytoplasm, cytoskeleton. Note=According to PubMed:7540613, localizes to nuclear dots. According to PubMed:9230084 and PubMed:12869526, it is not a nuclear dot- associated protein but localizes predominantly in the cytoplasm with a coarse-grained distribution preferentially close to the nucleus. |
Tissue Specificity | Expressed in all tissues tested with highest expression in skeletal muscle and lowest in brain. {ECO:0000269|PubMed:7540613}. |
SignalSilence ® NDP52 siRNA II - 9000 from Cell Signaling Technology
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SignalSilence ® NDP52 siRNA I - 8964 from Cell Signaling Technology
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CALCOCO2 CRISPR/Cas9 KO Plasmid (h) - sc-416970 from Santa Cruz Biotechnology
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CALCOCO2 HDR Plasmid (h) - sc-416970-HDR from Santa Cruz Biotechnology
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CALCOCO2 Double Nickase Plasmid (h) - sc-416970-NIC from Santa Cruz Biotechnology
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CALCOCO2 Double Nickase Plasmid (h2) - sc-416970-NIC-2 from Santa Cruz Biotechnology
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CALCOCO2 CRISPR Activation Plasmid (h) - sc-416970-ACT from Santa Cruz Biotechnology
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CALCOCO2 CRISPR Activation Plasmid (h2) - sc-416970-ACT-2 from Santa Cruz Biotechnology
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CALCOCO2 Lentiviral Activation Particles (h) - sc-416970-LAC from Santa Cruz Biotechnology
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CALCOCO2 Lentiviral Activation Particles (h2) - sc-416970-LAC-2 from Santa Cruz Biotechnology
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CALCOCO2 siRNA (h) - sc-93738 from Santa Cruz Biotechnology
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CALCOCO2 shRNA Plasmid (h) - sc-93738-SH from Santa Cruz Biotechnology
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CALCOCO2 shRNA (h) Lentiviral Particles - sc-93738-V from Santa Cruz Biotechnology
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NDP52 RNAi - H00010241-R01 from Novus Biologicals
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MISSION® esiRNA - EHU033821 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5294 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5294 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10457 from Sigma-Aldrich
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CALCOCO2 siRNA (Human) - CRH6928 from Cohesion Biosciences
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CALCOCO2 - MBS8237359 from MyBioSource
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shRNA set against Human CALCOCO2 (NM_005831.4) - SHH253729 from Creative biogene
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Human CALCOCO2 siRNA - orb267430 from Biorbyt
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CALCOCO2 shRNA Plasmid (Human) - CHH6928 from Cohesion Biosciences
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CALCOCO2 miRNA 3'UTR clone - MiUTR3H-06932 from Creative biogene
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