| Gene Symbol |
SLC6A19
|
| Entrez Gene |
340024
|
| Alt Symbol |
B0AT1, HND
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 6 (neutral amino acid transporter), member 19
|
| Other Description |
sodium-dependent amino acid transporter system B0|sodium-dependent neutral amino acid transporter B(0)AT1|solute carrier family 6 (neurotransmitter transporter), member 19|solute carrier family 6 member 19|system B(0) neutral amino acid transporter AT1|system B0 neutral amino acid transporter
|
| Swissprots |
Q695T7 A8K446
|
| Accessions |
EAX08174 EAX08175 Q695T7 AI015994 AK000687 AK091954 AK096054 BAG53204 AK123779 BAG53960 AK290811 BAF83500 AY591756 AAT66171 AY596807 AAT42127 BC146290 AAI46291 BC148801 AAI48802 NM_001003841 NP_001003841
|
| Function |
Transporter that mediates epithelial resorption of neutral amino acids across the apical membrane of epithelial cells in the kidney and intestine. It appears that leucine is the preferred substrate, but all large neutral non-aromatic L-amino acids bind to this transporter. Uptake of leucine is sodium- dependent. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Robust expression in kidney and small intestine, with minimal expression in pancreas. Also expressed in stomach, liver, duodenum, ileocecum, colon and prostate. Not detected in testis, whole brain, cerebellum, fetal liver, spleen, skeletal muscle, uterus, heart or lung. {ECO:0000269|PubMed:15286787, ECO:0000269|PubMed:15286788}.
|
| Top Pathways |
Protein digestion and absorption, Mineral absorption
|