Gene Symbol | SLC6A19 |
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Entrez Gene | 340024 |
Alt Symbol | B0AT1, HND |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 6 (neutral amino acid transporter), member 19 |
Other Description | sodium-dependent amino acid transporter system B0|sodium-dependent neutral amino acid transporter B(0)AT1|solute carrier family 6 (neurotransmitter transporter), member 19|solute carrier family 6 member 19|system B(0) neutral amino acid transporter AT1|system B0 neutral amino acid transporter |
Swissprots | Q695T7 A8K446 |
Accessions | EAX08174 EAX08175 Q695T7 AI015994 AK000687 AK091954 AK096054 BAG53204 AK123779 BAG53960 AK290811 BAF83500 AY591756 AAT66171 AY596807 AAT42127 BC146290 AAI46291 BC148801 AAI48802 NM_001003841 NP_001003841 |
Function | Transporter that mediates epithelial resorption of neutral amino acids across the apical membrane of epithelial cells in the kidney and intestine. It appears that leucine is the preferred substrate, but all large neutral non-aromatic L-amino acids bind to this transporter. Uptake of leucine is sodium- dependent. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity). {ECO:0000250}. |
Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
Tissue Specificity | Robust expression in kidney and small intestine, with minimal expression in pancreas. Also expressed in stomach, liver, duodenum, ileocecum, colon and prostate. Not detected in testis, whole brain, cerebellum, fetal liver, spleen, skeletal muscle, uterus, heart or lung. {ECO:0000269|PubMed:15286787, ECO:0000269|PubMed:15286788}. |
Top Pathways | Protein digestion and absorption, Mineral absorption |
SLC6A19 (H-98) - sc-368469 from Santa Cruz Biotechnology
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SLC6A19 (N-19) - sc-160811 from Santa Cruz Biotechnology
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SLC6A19 (P-18) - sc-160812 from Santa Cruz Biotechnology
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SLC6A19 (Y-15) - sc-160813 from Santa Cruz Biotechnology
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Anti-SLC6A19 antibody - ab58036 from Abcam
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Anti-SLC6A19 antibody [EPR14154(B)] - ab180516 from Abcam
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Anti-SLC6A19 Antibody IHC-plus⢠- LS-B9490 from LifeSpan Bioscience
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SLC6A19 Antibody - NBP1-86277 from Novus Biologicals
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SLC6A19 Antibody - H00340024-A01 from Novus Biologicals
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SLC6A19 Antibody (4F11) - H00340024-M01 from Novus Biologicals
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Anti-SLC6A19 antibody produced in rabbit - HPA037415 from Sigma-Aldrich
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Monoclonal Anti-SLC6A19 antibody produced in mouse - WH0340024M1 from Sigma-Aldrich
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SLC6A19 antibody - orb11377 from Biorbyt
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SLC6A19 antibody (FITC) - orb16318 from Biorbyt
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SLC6A19 / B0AT1 antibody - H00340024-A01 from Acris Antibodies
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SLC6A19 / B0AT1 antibody - H00340024-M01 from Acris Antibodies
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SLC6A19 Antibody - 40215 from Signalway Antibody
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SLC6A19, Monoclonal Antibody - MBS6009385 from MyBioSource
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Anti-SLC6A19 (aa 326-414) polyclonal antibody - DPAB-DC1655 from Creative Diagnostics
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Anti-SLC6A19 monoclonal antibody, clone FQS25265(C) - DCABH-6848 from Creative Diagnostics
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Anti-solute carrier family 6 (neutral amino acid transporter), member 19 - 08A340024 from MP Biomedicals
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SLC6A19 (4F11) - sc-293399 from Santa Cruz Biotechnology
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SLC6A19, Polyclonal Antibody - MBS9404862 from MyBioSource
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SLC6A19-Antibody-C-Term - AP22057b from Abgent, a WuXi AppTec company
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SLC6A19 (M-43) - sc-368470 from Santa Cruz Biotechnology
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