| Gene Symbol |
CREB3L1
|
| Entrez Gene |
90993
|
| Alt Symbol |
OASIS
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cAMP responsive element binding protein 3-like 1
|
| Other Description |
BBF-2 homolog|cAMP-responsive element-binding protein 3-like protein 1|cyclic AMP-responsive element-binding protein 3-like protein 1|old astrocyte specifically-induced substance
|
| Swissprots |
Q8N2D5 Q96BA8 Q96CP0
|
| Accessions |
EAW68010 Q96BA8 AB063321 BAC01278 AF055009 AK075538 BAC11681 AK314072 BAG36772 BC014097 AAH14097 BC015781 AAH15781 BQ953032 CF131922 DA693632 DQ895809 ABM86735 EU176365 ABW03816 XM_006718380 XP_006718443 NM_052854 NP_443086
|
| Function |
Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system (By similartity). May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:12054625, ECO:0000269|PubMed:16417584}; Single-pass type II membrane protein {ECO:0000269|PubMed:12054625, ECO:0000269|PubMed:16417584}.
|
| Tissue Specificity |
Ubiquitously expressed with high levels in pancreas and prostate. Expressed at relatively lower levels in brain. {ECO:0000269|PubMed:12054625}.
|
| Top Pathways |
cGMP-PKG signaling pathway, Huntington's disease, Glucagon signaling pathway, Prostate cancer, PI3K-Akt signaling pathway
|