Gene Symbol | CREB3L1 |
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Entrez Gene | 90993 |
Alt Symbol | OASIS |
Species | Human |
Gene Type | protein-coding |
Description | cAMP responsive element binding protein 3-like 1 |
Other Description | BBF-2 homolog|cAMP-responsive element-binding protein 3-like protein 1|cyclic AMP-responsive element-binding protein 3-like protein 1|old astrocyte specifically-induced substance |
Swissprots | Q8N2D5 Q96BA8 Q96CP0 |
Accessions | EAW68010 Q96BA8 AB063321 BAC01278 AF055009 AK075538 BAC11681 AK314072 BAG36772 BC014097 AAH14097 BC015781 AAH15781 BQ953032 CF131922 DA693632 DQ895809 ABM86735 EU176365 ABW03816 XM_006718380 XP_006718443 NM_052854 NP_443086 |
Function | Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system (By similartity). May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE (By similarity). {ECO:0000250}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:12054625, ECO:0000269|PubMed:16417584}; Single-pass type II membrane protein {ECO:0000269|PubMed:12054625, ECO:0000269|PubMed:16417584}. |
Tissue Specificity | Ubiquitously expressed with high levels in pancreas and prostate. Expressed at relatively lower levels in brain. {ECO:0000269|PubMed:12054625}. |
Top Pathways | cGMP-PKG signaling pathway, Huntington's disease, Glucagon signaling pathway, Prostate cancer, PI3K-Akt signaling pathway |
CREB3L1 CRISPR/Cas9 KO Plasmid (h) - sc-405316 from Santa Cruz Biotechnology
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CREB3L1 HDR Plasmid (h) - sc-405316-HDR from Santa Cruz Biotechnology
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CREB3L1 Double Nickase Plasmid (h) - sc-405316-NIC from Santa Cruz Biotechnology
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CREB3L1 Double Nickase Plasmid (h2) - sc-405316-NIC-2 from Santa Cruz Biotechnology
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CREB3L1 CRISPR Activation Plasmid (h) - sc-405316-ACT from Santa Cruz Biotechnology
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CREB3L1 CRISPR Activation Plasmid (h2) - sc-405316-ACT-2 from Santa Cruz Biotechnology
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CREB3L1 Lentiviral Activation Particles (h) - sc-405316-LAC from Santa Cruz Biotechnology
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CREB3L1 Lentiviral Activation Particles (h2) - sc-405316-LAC-2 from Santa Cruz Biotechnology
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CREB3L1 siRNA (h) - sc-72995 from Santa Cruz Biotechnology
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CREB3L1 shRNA Plasmid (h) - sc-72995-SH from Santa Cruz Biotechnology
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CREB3L1 shRNA (h) Lentiviral Particles - sc-72995-V from Santa Cruz Biotechnology
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OASIS/CREB3L1 RNAi - H00090993-R01 from Novus Biologicals
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MISSION® esiRNA - EHU139201 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6553 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6553 from Sigma-Aldrich
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CREB3L1 siRNA (Human) - CRJ4003 from Cohesion Biosciences
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CREB3L1 - MBS8232880 from MyBioSource
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shRNA set against Human CREB3L1 (NM_052854.2) - SHH269309 from Creative biogene
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shRNA set against Human CREB3L1(NM_052854.2) - SHG198097 from Creative biogene
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Human CREB3L1 siRNA - orb274504 from Biorbyt
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CREB3L1 shRNA Plasmid (Human) - CHJ4003 from Cohesion Biosciences
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CREB3L1 miRNA 3'UTR clone - MiUTR1H-02411 from Creative biogene
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