Gene Symbol | YWHAH |
---|---|
Entrez Gene | 7533 |
Alt Symbol | YWHA1 |
Species | Human |
Gene Type | protein-coding |
Description | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta |
Other Description | 14-3-3 eta|14-3-3 protein eta|tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide |
Swissprots | Q04917 |
Accessions | BAA11418 CAA56676 EAW60001 EAW60002 EAW60003 Q04917 AK307750 AK312650 BAG35533 AY007132 AAG01995 BC003047 AAH03047 CR456612 CAG30498 CU013208 CAK54639 CU013496 CAK54938 L08439 L20422 AAA35483 S80794 AAB36036 X57345 CAA40620 X78138 CAA55017 NM_003405 NP_003396 |
Function | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}. |
Tissue Specificity | Expressed mainly in the brain and present in other tissues albeit at lower levels. |
Top Pathways | Cell cycle, Oocyte meiosis, Viral carcinogenesis, PI3K-Akt signaling pathway, Epstein-Barr virus infection |