Gene Symbol | YWHAH |
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Entrez Gene | 7533 |
Alt Symbol | YWHA1 |
Species | Human |
Gene Type | protein-coding |
Description | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta |
Other Description | 14-3-3 eta|14-3-3 protein eta|tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide |
Swissprots | Q04917 |
Accessions | BAA11418 CAA56676 EAW60001 EAW60002 EAW60003 Q04917 AK307750 AK312650 BAG35533 AY007132 AAG01995 BC003047 AAH03047 CR456612 CAG30498 CU013208 CAK54639 CU013496 CAK54938 L08439 L20422 AAA35483 S80794 AAB36036 X57345 CAA40620 X78138 CAA55017 NM_003405 NP_003396 |
Function | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}. |
Tissue Specificity | Expressed mainly in the brain and present in other tissues albeit at lower levels. |
Top Pathways | Cell cycle, Oocyte meiosis, Viral carcinogenesis, PI3K-Akt signaling pathway, Epstein-Barr virus infection |
14-3-3 η siRNA (h) - sc-43581 from Santa Cruz Biotechnology
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14-3-3 η shRNA Plasmid (h) - sc-43581-SH from Santa Cruz Biotechnology
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14-3-3 η shRNA (h) Lentiviral Particles - sc-43581-V from Santa Cruz Biotechnology
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14-3-3 eta RNAi - H00007533-R01 from Novus Biologicals
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MISSION® esiRNA - EHU004271 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN23033 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND23033 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12391 from Sigma-Aldrich
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YWHAH siRNA (Human) - CRH5146 from Cohesion Biosciences
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YWHAH - MBS8231385 from MyBioSource
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shRNA set against Human YWHAH (NM_003405.3) - SHH448700 from Creative biogene
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shRNA set against Human YWHAH(NM_003405.3) - SHL132588 from Creative biogene
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Human YWHAH siRNA - orb265648 from Biorbyt
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YWHAH shRNA Plasmid (Human) - CHH5146 from Cohesion Biosciences
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YWHAH miRNA 3'UTR clone - MiUTR1H-11349 from Creative biogene
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