GIT1

Gene Symbol GIT1
Entrez Gene 28964
Alt Symbol -
Species Human
Gene Type protein-coding
Description G protein-coupled receptor kinase interacting ArfGAP 1
Other Description ARF GAP GIT1|ARF GTPase-activating protein GIT1|CAT-1|CAT1|G protein-coupled receptor kinase interactor 1|G protein-coupled receptor kinase-interactor 1|GRK-interacting protein 1|cool-associated and tyrosine-phosphorylated protein 1
Swissprots Q9BRJ4 Q86SS0 B4DSV3 B4DGU9 Q9Y2X7
Accessions CCO13736 EAW51196 EAW51197 Q9Y2X7 AB209537 BAD92774 AF124490 AAD28046 AK000863 AK024826 AK294785 BAG57910 AK297443 BAG59869 AK299615 BAG61543 AK299932 BAG61765 BC001369 BC005031 AAH05031 BC006227 AAH06227 BC018998 BC032098 AAH32098 BC048196 AAH48196 BC067358 BM984210 BQ424386 BX537553 CAD97779 BX537554 CAD97780 BX648097 CF994106 DR001908 XM_011524684 XP_011522986 XM_011524685 XP_011522987 NM_001085454 NP_001078923 NM_014030 NP_054749
Function GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine- phosphorylated paxillin in cytoplasmic complexes. Involved in the regulation of cytokinesis; the function may involve SDCCAG3 and PTPN13 (By similarity). {ECO:0000250|UniProtKB:Q68FF6, ECO:0000269|PubMed:11896197}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:11896197}. Note=Cycles between at least 3 distinct intracellular compartments, including focal adhesions, cytoplasmic complexes and membrane protrusions. During cell migration, when cells detach, moves from the adhesions into the cytoplasmic complexes towards the leading edge, while, when cells adhere, it is found in vinculin-containing adhesions. Recruitment to adhesions may be mediated by active tyrosine-phosphorylated paxillin.
Top Pathways Epithelial cell signaling in Helicobacter pylori infection, Endocytosis, Regulation of actin cytoskeleton

GIT1 overexpression lysate - LY415510 from Acris Antibodies

Category Cell Lysate
Prices $480.00
Sizes 100 µg

GIT1 293 Cell Lysate - 407308 from ABBIOTEC

Category Cell Lysate
Prices $672.00
Sizes 100 µg

GIT1 Overexpression Lysate (Native) - NBP2-07386 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg
Western Blot: GIT1 Overexpression Lysate (Adult Normal) [NBP2-07386] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for GIT1.

GIT1 Over-expression Lysate Product - GWB-332A25 from Genway Biotech

Category Cell Lysate
Prices $756.00
Sizes 100 µg
Species Human

Panoply™ Human GIT1 Knockdown Stable Cell Line - CSC-DC006275 from Creative biogene

Category Cell Line
Species Human

Human GIT1 Knockout Cell Line-HeLa - CSC-RT1727 from Creative biogene

Category Cell Line
Species Human

GIT1 KO Cell Lysate-HeLa - CLKO-1574 from Creative biogene

Category Cell Lysate
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