Gene Symbol | GIT1 |
---|---|
Entrez Gene | 28964 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | G protein-coupled receptor kinase interacting ArfGAP 1 |
Other Description | ARF GAP GIT1|ARF GTPase-activating protein GIT1|CAT-1|CAT1|G protein-coupled receptor kinase interactor 1|G protein-coupled receptor kinase-interactor 1|GRK-interacting protein 1|cool-associated and tyrosine-phosphorylated protein 1 |
Swissprots | Q9BRJ4 Q86SS0 B4DSV3 B4DGU9 Q9Y2X7 |
Accessions | CCO13736 EAW51196 EAW51197 Q9Y2X7 AB209537 BAD92774 AF124490 AAD28046 AK000863 AK024826 AK294785 BAG57910 AK297443 BAG59869 AK299615 BAG61543 AK299932 BAG61765 BC001369 BC005031 AAH05031 BC006227 AAH06227 BC018998 BC032098 AAH32098 BC048196 AAH48196 BC067358 BM984210 BQ424386 BX537553 CAD97779 BX537554 CAD97780 BX648097 CF994106 DR001908 XM_011524684 XP_011522986 XM_011524685 XP_011522987 NM_001085454 NP_001078923 NM_014030 NP_054749 |
Function | GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine- phosphorylated paxillin in cytoplasmic complexes. Involved in the regulation of cytokinesis; the function may involve SDCCAG3 and PTPN13 (By similarity). {ECO:0000250|UniProtKB:Q68FF6, ECO:0000269|PubMed:11896197}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11896197}. Note=Cycles between at least 3 distinct intracellular compartments, including focal adhesions, cytoplasmic complexes and membrane protrusions. During cell migration, when cells detach, moves from the adhesions into the cytoplasmic complexes towards the leading edge, while, when cells adhere, it is found in vinculin-containing adhesions. Recruitment to adhesions may be mediated by active tyrosine-phosphorylated paxillin. |
Top Pathways | Epithelial cell signaling in Helicobacter pylori infection, Endocytosis, Regulation of actin cytoskeleton |
GIT1 CRISPR/Cas9 KO Plasmid (h) - sc-402136 from Santa Cruz Biotechnology
|
||||||||
GIT1 HDR Plasmid (h) - sc-402136-HDR from Santa Cruz Biotechnology
|
||||||||
GIT1 Double Nickase Plasmid (h) - sc-402136-NIC from Santa Cruz Biotechnology
|
||||||||
GIT1 Double Nickase Plasmid (h2) - sc-402136-NIC-2 from Santa Cruz Biotechnology
|
||||||||
GIT1 CRISPR Activation Plasmid (h) - sc-402136-ACT from Santa Cruz Biotechnology
|
||||||||
GIT1 CRISPR Activation Plasmid (h2) - sc-402136-ACT-2 from Santa Cruz Biotechnology
|
||||||||
GIT1 Lentiviral Activation Particles (h) - sc-402136-LAC from Santa Cruz Biotechnology
|
||||||||
GIT1 Lentiviral Activation Particles (h2) - sc-402136-LAC-2 from Santa Cruz Biotechnology
|
||||||||
GIT1 siRNA (h) - sc-35477 from Santa Cruz Biotechnology
|
||||||||
GIT1 shRNA Plasmid (h) - sc-35477-SH from Santa Cruz Biotechnology
|
||||||||
GIT1 shRNA (h) Lentiviral Particles - sc-35477-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU098741 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN9300 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9300 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR08828 from Sigma-Aldrich
|
||||||||
GIT1 siRNA (Human) - CRH9131 from Cohesion Biosciences
|
||||||||
GIT1 RNAi - H00028964-R01 from Novus Biologicals
|
||||||||
GIT1 - MBS8210281 from MyBioSource
|
||||||||
shRNA set against Human GIT1 (NM_014030.3) - SHH301258 from Creative biogene
|
||||||||
shRNA set against Human GIT1(NM_014030.3) - SHH085193 from Creative biogene
|
||||||||
Human GIT1 siRNA - orb269633 from Biorbyt
|
||||||||
GIT1 shRNA Plasmid (Human) - CHH9131 from Cohesion Biosciences
|
||||||||
GIT1 miRNA 3'UTR clone - MiUTR1H-04040 from Creative biogene
|
||||||||
GIT1 miRNA 3'UTR clone - MiUTR3H-09998 from Creative biogene
|