GIT1

Gene Symbol	GIT1
Entrez Gene	28964
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	G protein-coupled receptor kinase interacting ArfGAP 1
Other Description	ARF GAP GIT1|ARF GTPase-activating protein GIT1|CAT-1|CAT1|G protein-coupled receptor kinase interactor 1|G protein-coupled receptor kinase-interactor 1|GRK-interacting protein 1|cool-associated and tyrosine-phosphorylated protein 1
Swissprots	Q9BRJ4 Q86SS0 B4DSV3 B4DGU9 Q9Y2X7
Accessions	CCO13736 EAW51196 EAW51197 Q9Y2X7 AB209537 BAD92774 AF124490 AAD28046 AK000863 AK024826 AK294785 BAG57910 AK297443 BAG59869 AK299615 BAG61543 AK299932 BAG61765 BC001369 BC005031 AAH05031 BC006227 AAH06227 BC018998 BC032098 AAH32098 BC048196 AAH48196 BC067358 BM984210 BQ424386 BX537553 CAD97779 BX537554 CAD97780 BX648097 CF994106 DR001908 XM_011524684 XP_011522986 XM_011524685 XP_011522987 NM_001085454 NP_001078923 NM_014030 NP_054749
Function	GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine- phosphorylated paxillin in cytoplasmic complexes. Involved in the regulation of cytokinesis; the function may involve SDCCAG3 and PTPN13 (By similarity). {ECO:0000250|UniProtKB:Q68FF6, ECO:0000269|PubMed:11896197}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:11896197}. Note=Cycles between at least 3 distinct intracellular compartments, including focal adhesions, cytoplasmic complexes and membrane protrusions. During cell migration, when cells detach, moves from the adhesions into the cytoplasmic complexes towards the leading edge, while, when cells adhere, it is found in vinculin-containing adhesions. Recruitment to adhesions may be mediated by active tyrosine-phosphorylated paxillin.
Top Pathways	Epithelial cell signaling in Helicobacter pylori infection, Endocytosis, Regulation of actin cytoskeleton

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

GIT1 Antibody Blocking Peptide - LS-E22464 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GIT1 Antibody Blocking Peptide - LS-E8936 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GIT1 Antibody Blocking Peptide - LS-E7417 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GIT1 Peptide - P1683 from Novus Biologicals Category Peptide Species Human

Phospho-GIT1Y554-Antibody-Blocking-peptide - BP3553a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

GIT1-Antibody-Center-Blocking-Peptide - BP7416c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

GIT1-Antibody-C-term-Blocking-Peptide - BP7416b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

GIT1-Antibody-Y510-Blocking-Peptide - BP7416a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

GIT1 Blocking Peptide - abx063829 from Abbexa Category Peptide Species Human, Mouse

GIT1 fusion protein - Ag10658 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

GIT1 fusion protein - Ag10517 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

GIT1 fusion protein - Ag24648 from Proteintech Group Category Protein Prices $199.00 Sizes 50 Source E. coli -derived, PGEX-4T Species Human

Recombinant Human GIT1, His-tagged - GIT1-13268H from Creative Biomart Category Protein Source E.coli Species Human

GIT1 Blocking Peptide - CBP2635 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse

GIT1 fusion protein - Ag24638 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET30a Species Human

GIT1 (transcript variant 2) - TP320153 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

GIT1 Recombinant Protein Antigen - NBP1-85798PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

GIT1 Recombinant Protein Antigen - NBP1-86144PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Phospho-GIT1Y510-Antibody-Blocking-peptide - BP3566a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

Phospho-GIT1S375-Antibody-Blocking-peptide - BP3552a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

GIT1-S388-Antibody-Blocking-peptide - BP3734b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Phospho-GIT1S700-Antibody-Blocking-peptide - BP3683a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

GIT1-Y554-Antibody-C-term-Blocking-peptide - BP7416d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Phospho-GIT1S388-Blocking-Peptide - BP3734a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

GIT1-S388-Blocking-Peptide-Center - BP7416f from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Search more