CLEC4A

Gene Symbol	CLEC4A
Entrez Gene	50856
Alt Symbol	CLECSF6, DCIR, DDB27, HDCGC13P, LLIR
Species	Human
Gene Type	protein-coding
Description	C-type lectin domain family 4, member A
Other Description	C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 6|C-type lectin DDB27|C-type lectin domain family 4 member A|C-type lectin superfamily member 6|dendritic cell immunoreceptor|lectin-like immunoreceptor
Swissprots	Q17R69 Q9UI34 Q9H2Z9 Q9UMR7 Q9NS33 Q8WXW9
Accessions	EAW88632 EAW88633 EAW88634 EAW88635 Q9UMR7 AA418441 AF067800 AAF75560 AF109146 AAF14348 AF200738 AAG35593 AF328684 AAL56016 AI400631 AJ133532 CAB54001 BC074822 AAH74822 BC074874 AAH74874 BC117439 AAI17440 BC117441 AAI17442 EU196761 HQ258754 ADR83505 XM_011520684 XP_011518986 NM_016184 NP_057268 NM_194447 NP_919429 NM_194448 NP_919430 NM_194450 NP_919432
Function	May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. {ECO:0000269|PubMed:10438934}.
Subcellular Location	Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Tissue Specificity	Expressed in dendritic cells, myeloid cells, B-cells and HL-60 cells (at protein level). TNF alpha, IL-1 alpha, and LPS, down-regulated expression at the surface of neutrophils (at protein level). Expressed preferentially in hematopoietic tissues. Expressed in peripheral blood leukocytes, neutrophils, moderate quantities in spleen, lymph node, and bone marrow, and at very low levels in thymus. Expressed in Ag-presenting cells (DC, monocytes, macrophages and B-cells), as well as on granulocytes. Expression was decreased in DC by signals inducing its maturation (e.g. CD40 ligand, LPS, and TNF alpha). {ECO:0000269|PubMed:10438934, ECO:0000269|PubMed:11178971, ECO:0000269|PubMed:11994513}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DCIR (G-9) - sc-374583 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

DCIR (C-12) - sc-46902 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

DCIR (H-47) - sc-67160 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

DCIR (N-19) - sc-46903 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-CLECSF6 antibody - ab197339 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-CLECSF6 antibody - ab127025 from Abcam Prices $370.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-CLECSF6 antibody - ab172486 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-CLECSF6 antibody [MM0237- 5P20] - ab89188 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone MM0237- 5P20

Anti-CLECSF6 / DCIR Antibody (aa70-238, clone 320507, PE) - LS-C127566 from LifeSpan Bioscience Prices $530.00 Sizes 100 tst Host Rat Clonality Monoclonal Clone 320507

Anti-CLECSF6 / DCIR Antibody - LS-C307185 from LifeSpan Bioscience Prices $455.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-CLECSF6 / DCIR Antibody - LS-C341477 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-CLECSF6 / DCIR Antibody - LS-C335268 from LifeSpan Bioscience Prices $255.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

DCIR/CLEC4A Antibody [Unconjugated] - AF1748 from Novus Biologicals Prices $99.00, $359.00 Sizes 25 µg, 100 µg Host Goat Clonality Polyclonal

DCIR/CLEC4A Antibody - NBP2-15916 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

DCIR/CLEC4A Antibody (111F8.04) - DDX0180P-100 from Novus Biologicals Prices $279.00, $329.00 Sizes 50 µg, 100 µg Host Mouse Clonality Monoclonal Clone 111F8.04

DCIR/CLEC4A Antibody - NBP1-84446 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

DCIR/CLEC4A Antibody - H00050856-B01P from Novus Biologicals Prices $359.00 Sizes 50 µg Host Mouse Clonality Polyclonal

DCIR/CLEC4A Antibody - H00050856-B01 from Novus Biologicals Prices $349.00 Sizes 50 µl Host Mouse Clonality Polyclonal

DCIR/CLEC4A Antibody (MM0237-5P20) - NBP2-12257 from Novus Biologicals Prices $349.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone MM0237-5P20

DCIR/CLEC4A Antibody (216110) [Phycoerythrin] - FAB1748P from Novus Biologicals Prices $299.00 Sizes 100 tests Host Mouse Clonality Monoclonal Clone 216110

DCIR/CLEC4A Antibody (216110) [Allophycocyanin] - FAB1748A from Novus Biologicals Prices $339.00 Sizes 100 tests Host Mouse Clonality Monoclonal Clone 216110

DCIR/CLEC4A Antibody [Biotin] - BAF1748 from Novus Biologicals Prices $390.00 Sizes 50 µg Host Goat Clonality Polyclonal

DCIR/CLEC4A Antibody (216110) [Fluorescein] - FAB1748F from Novus Biologicals Prices $239.00 Sizes 100 tests Host Mouse Clonality Monoclonal Clone 216110

DCIR/CLEC4A Antibody (111F8.04) [PE] - DDX0180PE from Novus Biologicals Host Mouse Clonality Monoclonal Clone 111F8.04

DCIR/CLEC4A Antibody (111F8.04) [Alexa Fluor (R) 488] - DDX0180A488-100 from Novus Biologicals Host Mouse Clonality Monoclonal Clone 111F8.04

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