CLEC4A

Gene Symbol	CLEC4A
Entrez Gene	50856
Alt Symbol	CLECSF6, DCIR, DDB27, HDCGC13P, LLIR
Species	Human
Gene Type	protein-coding
Description	C-type lectin domain family 4, member A
Other Description	C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 6|C-type lectin DDB27|C-type lectin domain family 4 member A|C-type lectin superfamily member 6|dendritic cell immunoreceptor|lectin-like immunoreceptor
Swissprots	Q17R69 Q9UI34 Q9H2Z9 Q9UMR7 Q9NS33 Q8WXW9
Accessions	EAW88632 EAW88633 EAW88634 EAW88635 Q9UMR7 AA418441 AF067800 AAF75560 AF109146 AAF14348 AF200738 AAG35593 AF328684 AAL56016 AI400631 AJ133532 CAB54001 BC074822 AAH74822 BC074874 AAH74874 BC117439 AAI17440 BC117441 AAI17442 EU196761 HQ258754 ADR83505 XM_011520684 XP_011518986 NM_016184 NP_057268 NM_194447 NP_919429 NM_194448 NP_919430 NM_194450 NP_919432
Function	May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. {ECO:0000269|PubMed:10438934}.
Subcellular Location	Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Tissue Specificity	Expressed in dendritic cells, myeloid cells, B-cells and HL-60 cells (at protein level). TNF alpha, IL-1 alpha, and LPS, down-regulated expression at the surface of neutrophils (at protein level). Expressed preferentially in hematopoietic tissues. Expressed in peripheral blood leukocytes, neutrophils, moderate quantities in spleen, lymph node, and bone marrow, and at very low levels in thymus. Expressed in Ag-presenting cells (DC, monocytes, macrophages and B-cells), as well as on granulocytes. Expression was decreased in DC by signals inducing its maturation (e.g. CD40 ligand, LPS, and TNF alpha). {ECO:0000269|PubMed:10438934, ECO:0000269|PubMed:11178971, ECO:0000269|PubMed:11994513}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CLECSF6 full length protein - ab162371 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human DCIR/CLEC4A Protein - H00050856-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Human CLEC4A His tag protein - orb83847 from Biorbyt Category Protein Prices $323.00, $612.00 Sizes 20 μg, 50 μg Source Human Species Human

CLEC4A - H00050856-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CLEC4A - H00050856-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

CLEC4A fusion protein - ag12646 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

CLEC4A fusion protein - ag12609 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human CLEC4A, His tagged - CLEC4A-3353H from Creative Biomart Category Protein Source Human Cells Species Human

CLEC4A - PN201348 from Elabscience Category Protein Prices $225.00, $475.00 Sizes 10 μg, 50 μg Source Human Cells Species Human

DCIR - PN201483 from Elabscience Category Protein Prices $225.00, $475.00 Sizes 10 μg, 50 μg Source Human Cells Species Human

Human CLEC4A / CLECSF6 / DCIR Protein (His Tag) - 11476-H07H-20 from Sino Biological Category Protein Source Human Cells Species Human

Recombinant Human C-type lectin domain family 4 member A(CLEC4A) - CSB-YP891558HU CSB-EP891558HU CSB-BP891558HU CSB-MP891558HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

C-type lectin domain family 4 member A (CLEC4A), Recombinant Protein - MBS1281256 from MyBioSource Category Protein Prices $910.00, $910.00, $1,135.00, $1,135.00, $1,350.00, $1,350.00, $1,805.00, $1,805.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Recombinant Human CLEC4A / CLECSF6 / DCIR Protein (His tag) - PKSH031113 from Elabscience Category Protein Source Human Cell Species Human

DCIR/CLEC4A Recombinant Protein Antigen - NBP1-84446PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

CLEC4A Peptide, Human - M34GP03267H from Creative Peptides Category Peptide Source Synthetic. Species Human

DCIR Blocking Peptide - CBP7511 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human

Human CLEC4A / CLECSF6 / DCIR Protein (His Tag) - 11476-H07H from ABclonal Category Protein Prices $138.00, $298.00 Sizes 20 µg, 50 µg Source Human Cells Species Human

CLEC4A fusion protein - Ag25295 from Proteintech Group Category Protein Source E. coli -derived, PGEX-4T Species Human

CLEC4A peptide - orb382416 from Biorbyt Category Peptide Species Human

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