| Gene Symbol | CLEC4A |
|---|---|
| Entrez Gene | 50856 |
| Alt Symbol | CLECSF6, DCIR, DDB27, HDCGC13P, LLIR |
| Species | Human |
| Gene Type | protein-coding |
| Description | C-type lectin domain family 4, member A |
| Other Description | C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 6|C-type lectin DDB27|C-type lectin domain family 4 member A|C-type lectin superfamily member 6|dendritic cell immunoreceptor|lectin-like immunoreceptor |
| Swissprots | Q17R69 Q9UI34 Q9H2Z9 Q9UMR7 Q9NS33 Q8WXW9 |
| Accessions | EAW88632 EAW88633 EAW88634 EAW88635 Q9UMR7 AA418441 AF067800 AAF75560 AF109146 AAF14348 AF200738 AAG35593 AF328684 AAL56016 AI400631 AJ133532 CAB54001 BC074822 AAH74822 BC074874 AAH74874 BC117439 AAI17440 BC117441 AAI17442 EU196761 HQ258754 ADR83505 XM_011520684 XP_011518986 NM_016184 NP_057268 NM_194447 NP_919429 NM_194448 NP_919430 NM_194450 NP_919432 |
| Function | May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. {ECO:0000269|PubMed:10438934}. |
| Subcellular Location | Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. |
| Tissue Specificity | Expressed in dendritic cells, myeloid cells, B-cells and HL-60 cells (at protein level). TNF alpha, IL-1 alpha, and LPS, down-regulated expression at the surface of neutrophils (at protein level). Expressed preferentially in hematopoietic tissues. Expressed in peripheral blood leukocytes, neutrophils, moderate quantities in spleen, lymph node, and bone marrow, and at very low levels in thymus. Expressed in Ag-presenting cells (DC, monocytes, macrophages and B-cells), as well as on granulocytes. Expression was decreased in DC by signals inducing its maturation (e.g. CD40 ligand, LPS, and TNF alpha). {ECO:0000269|PubMed:10438934, ECO:0000269|PubMed:11178971, ECO:0000269|PubMed:11994513}. |