| Gene Symbol |
RAP2B
|
| Entrez Gene |
5912
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RAP2B, member of RAS oncogene family
|
| Other Description |
ras-related protein Rap-2b|small GTP binding protein
|
| Swissprots |
Q9CXG0 P17964 Q96EG5 P61225
|
| Accessions |
EAW78771 P61225 AF493915 AAM12629 AI718675 AL713766 CAI46163 AW997098 BC012362 AAH12362 BF965860 BI551390 BQ378964 BU507815 BU860799 BX116683 BX355341 CB116910 DQ891702 ABM82628 HY071303 X52987 CAA37178 NM_002886 NP_002877
|
| Function |
Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells. {ECO:0000269|PubMed:11877431, ECO:0000269|PubMed:15143162, ECO:0000269|PubMed:16540189}.
|
| Subcellular Location |
Recycling endosome membrane {ECO:0000269|PubMed:16540189}; Lipid-anchor {ECO:0000269|PubMed:16540189}; Cytoplasmic side {ECO:0000269|PubMed:16540189}. Note=Associated with red blood cells-released vesicles.
|
| Tissue Specificity |
Expressed in red blood cells (at protein level). {ECO:0000269|PubMed:16540189}.
|
![Western Blot: RAP2B Overexpression Lysate (Adult Normal) [NBL1-15149] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RAP2B.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6911_RAP2B%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15149-img0002.jpg)