Gene Symbol | NPPA |
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Entrez Gene | 4878 |
Alt Symbol | ANF, ANP, ATFB6, ATRST2, CDD, CDD-ANF, CDP, PND |
Species | Human |
Gene Type | protein-coding |
Description | natriuretic peptide A |
Other Description | atriopeptin|cardiodilatin|cardiodilatin-related peptide|cardionatrin|natriuretic peptide precursor A|natriuretic peptides A|prepronatriodilatin |
Swissprots | Q5JZE1 P01160 Q13766 |
Accessions | AAA35528 AAA35529 AAB59379 ACA05916 CAA25699 CAA25700 EAW71717 P01160 AA779538 BC005893 AAH05893 DQ893115 ABM84041 DQ896389 ABM87388 EU176780 ABW03581 K02044 AAA51730 M30262 AAA35669 NM_006172 NP_006163 |
Function | Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. {ECO:0000269|PubMed:1672777}. |
Subcellular Location | Secreted. |
ANP CRISPR/Cas9 KO Plasmid (h) - sc-400723 from Santa Cruz Biotechnology
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ANP HDR Plasmid (h) - sc-400723-HDR from Santa Cruz Biotechnology
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ANP Double Nickase Plasmid (h) - sc-400723-NIC from Santa Cruz Biotechnology
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ANP Double Nickase Plasmid (h2) - sc-400723-NIC-2 from Santa Cruz Biotechnology
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ANP CRISPR Activation Plasmid (h) - sc-400723-ACT from Santa Cruz Biotechnology
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ANP CRISPR Activation Plasmid (h2) - sc-400723-ACT-2 from Santa Cruz Biotechnology
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ANP Lentiviral Activation Particles (h) - sc-400723-LAC from Santa Cruz Biotechnology
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ANP Lentiviral Activation Particles (h2) - sc-400723-LAC-2 from Santa Cruz Biotechnology
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ANP siRNA (h) - sc-37062 from Santa Cruz Biotechnology
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ANP shRNA Plasmid (h) - sc-37062-SH from Santa Cruz Biotechnology
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ANP shRNA (h) Lentiviral Particles - sc-37062-V from Santa Cruz Biotechnology
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proANP RNAi - H00004878-R01 from Novus Biologicals
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MISSION® esiRNA - EHU153391 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15464 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15464 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02706 from Sigma-Aldrich
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NPPA siRNA (Human) - CRH3239 from Cohesion Biosciences
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ANP CRISPR/Cas9 KO Plasmid (h2) - sc-400723-KO-2 from Santa Cruz Biotechnology
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ANP HDR Plasmid (h2) - sc-400723-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human NPPA (NM_006172.3) - SHH354356 from Creative biogene
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Human NPPA siRNA - orb263741 from Biorbyt
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NPPA shRNA Plasmid (Human) - CHH3239 from Cohesion Biosciences
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NPPA miRNA 3'UTR clone - MiUTR4H-TG11871 from Creative biogene
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