| Gene Symbol |
CDNF
|
| Entrez Gene |
441549
|
| Alt Symbol |
ARMETL1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cerebral dopamine neurotrophic factor
|
| Other Description |
ARMET-like protein 1|arginine-rich, mutated in early stage tumors-like 1|conserved dopamine neurotrophic factor
|
| Swissprots |
B4DVW3 Q49AH0 A2RUU0
|
| Accessions |
EAW86263 EAW86264 EAW86265 EAW86266 Q49AH0 AK131035 AV657190 BC037872 AAH37872 BC133042 AAI33043 BC133044 AAI33045 BC144619 BG213461 BQ025443 CN311321 XM_011519488 XP_011517790 XM_011519489 XP_011517791 NM_001029954 NP_001025125
|
| Function |
Trophic factor for dopamine neurons. Prevents the 6- hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:17611540, ECO:0000269|PubMed:18561914}.
|
| Tissue Specificity |
Widely expressed in neuronal and non-neuronal tissues. In the brain, highest levels in the optic nerve and corpus callosum. {ECO:0000269|PubMed:17611540}.
|
