Gene Symbol | CDNF |
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Entrez Gene | 441549 |
Alt Symbol | ARMETL1 |
Species | Human |
Gene Type | protein-coding |
Description | cerebral dopamine neurotrophic factor |
Other Description | ARMET-like protein 1|arginine-rich, mutated in early stage tumors-like 1|conserved dopamine neurotrophic factor |
Swissprots | B4DVW3 Q49AH0 A2RUU0 |
Accessions | EAW86263 EAW86264 EAW86265 EAW86266 Q49AH0 AK131035 AV657190 BC037872 AAH37872 BC133042 AAI33043 BC133044 AAI33045 BC144619 BG213461 BQ025443 CN311321 XM_011519488 XP_011517790 XM_011519489 XP_011517791 NM_001029954 NP_001025125 |
Function | Trophic factor for dopamine neurons. Prevents the 6- hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity). {ECO:0000250}. |
Subcellular Location | Secreted {ECO:0000269|PubMed:17611540, ECO:0000269|PubMed:18561914}. |
Tissue Specificity | Widely expressed in neuronal and non-neuronal tissues. In the brain, highest levels in the optic nerve and corpus callosum. {ECO:0000269|PubMed:17611540}. |
CDNF CRISPR/Cas9 KO Plasmid (h) - sc-416049 from Santa Cruz Biotechnology
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CDNF HDR Plasmid (h) - sc-416049-HDR from Santa Cruz Biotechnology
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CDNF Double Nickase Plasmid (h) - sc-416049-NIC from Santa Cruz Biotechnology
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CDNF Double Nickase Plasmid (h2) - sc-416049-NIC-2 from Santa Cruz Biotechnology
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CDNF CRISPR Activation Plasmid (h) - sc-416049-ACT from Santa Cruz Biotechnology
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CDNF CRISPR Activation Plasmid (h2) - sc-416049-ACT-2 from Santa Cruz Biotechnology
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CDNF Lentiviral Activation Particles (h) - sc-416049-LAC from Santa Cruz Biotechnology
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CDNF Lentiviral Activation Particles (h2) - sc-416049-LAC-2 from Santa Cruz Biotechnology
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CDNF siRNA (h) - sc-90514 from Santa Cruz Biotechnology
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CDNF shRNA Plasmid (h) - sc-90514-SH from Santa Cruz Biotechnology
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CDNF shRNA (h) Lentiviral Particles - sc-90514-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU057851 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5870 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5870 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06086 from Sigma-Aldrich
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CDNF siRNA (Human) - CRJ8306 from Cohesion Biosciences
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CDNF - MBS8206023 from MyBioSource
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shRNA set against Human CDNF (NM_001029954.2) - SHH260929 from Creative biogene
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shRNA set against Human ARMETL1(NM_001029954.2) - SHG073675 from Creative biogene
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CDNF shRNA Plasmid (Human) - CHJ8306 from Cohesion Biosciences
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CDNF miRNA 3'UTR clone - MiUTR4H-TG10861 from Creative biogene
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