| Gene Symbol |
ACSL1
|
| Entrez Gene |
2180
|
| Alt Symbol |
ACS1, FACL1, FACL2, LACS, LACS1, LACS2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
acyl-CoA synthetase long-chain family member 1
|
| Other Description |
LACS 1|LACS 2|acyl-CoA synthetase 1|fatty-acid-Coenzyme A ligase, long-chain 1|fatty-acid-Coenzyme A ligase, long-chain 2|lignoceroyl-CoA synthase|long-chain acyl-CoA synthetase 1|long-chain acyl-CoA synthetase 2|long-chain fatty acid-CoA ligase 2|long-chain fatty-acid-coenzyme A ligase 1|long-chain-fatty-acid--CoA ligase 1|palmitoyl-CoA ligase 1|palmitoyl-CoA ligase 2|paltimoyl-CoA ligase 1
|
| Swissprots |
Q8TA99 P41215 Q8N8V7 D3DP57 P33121 B7Z452
|
| Accessions |
CBF64949 CBU89820 EAX04662 EAX04663 EAX04664 EAX04665 P33121 AK096117 BAC04704 AK292798 BAF85487 AK296550 BAH12385 AK296826 BAH12438 AK303486 BAG64522 BC026290 AAH26290 BC033479 BC050073 AAH50073 BG680610 BG773086 BI461964 BM982557 D10040 BAA00931 DC344113 DQ083028 AAZ30711 DQ083029 AAZ30712 L09229 AAB00959 XM_005262828 XP_005262885 XM_005262829 XP_005262886 XM_005262831 XP_005262888 XM_011531740 XP_011530042 XM_011531741 XP_011530043 XM_011531742 XP_011530044 XM_011531743 XP_011530045 NM_001286708 NP_001273637 NM_001286710 NP_001273639 NM_001286711 NP_001273640 NM_001286712 NP_001273641 NM_001995 NP_001986
|
| Function |
Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate.
|
| Subcellular Location |
Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in liver, heart, skeletal muscle, kidney and erythroid cells, and to a lesser extent in brain, lung, placenta and pancreas. {ECO:0000269|PubMed:10548543}.
|
| Top Pathways |
Adipocytokine signaling pathway, PPAR signaling pathway, Peroxisome, Fatty acid biosynthesis, Fatty acid degradation
|