ACSL1

Gene Symbol	ACSL1
Entrez Gene	2180
Alt Symbol	ACS1, FACL1, FACL2, LACS, LACS1, LACS2
Species	Human
Gene Type	protein-coding
Description	acyl-CoA synthetase long-chain family member 1
Other Description	LACS 1|LACS 2|acyl-CoA synthetase 1|fatty-acid-Coenzyme A ligase, long-chain 1|fatty-acid-Coenzyme A ligase, long-chain 2|lignoceroyl-CoA synthase|long-chain acyl-CoA synthetase 1|long-chain acyl-CoA synthetase 2|long-chain fatty acid-CoA ligase 2|long-chain fatty-acid-coenzyme A ligase 1|long-chain-fatty-acid--CoA ligase 1|palmitoyl-CoA ligase 1|palmitoyl-CoA ligase 2|paltimoyl-CoA ligase 1
Swissprots	Q8TA99 P41215 Q8N8V7 D3DP57 P33121 B7Z452
Accessions	CBF64949 CBU89820 EAX04662 EAX04663 EAX04664 EAX04665 P33121 AK096117 BAC04704 AK292798 BAF85487 AK296550 BAH12385 AK296826 BAH12438 AK303486 BAG64522 BC026290 AAH26290 BC033479 BC050073 AAH50073 BG680610 BG773086 BI461964 BM982557 D10040 BAA00931 DC344113 DQ083028 AAZ30711 DQ083029 AAZ30712 L09229 AAB00959 XM_005262828 XP_005262885 XM_005262829 XP_005262886 XM_005262831 XP_005262888 XM_011531740 XP_011530042 XM_011531741 XP_011530043 XM_011531742 XP_011530044 XM_011531743 XP_011530045 NM_001286708 NP_001273637 NM_001286710 NP_001273639 NM_001286711 NP_001273640 NM_001286712 NP_001273641 NM_001995 NP_001986
Function	Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate.
Subcellular Location	Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.
Tissue Specificity	Highly expressed in liver, heart, skeletal muscle, kidney and erythroid cells, and to a lesser extent in brain, lung, placenta and pancreas. {ECO:0000269|PubMed:10548543}.
Top Pathways	Adipocytokine signaling pathway, PPAR signaling pathway, Peroxisome, Fatty acid biosynthesis, Fatty acid degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ACSL1 Antibody - 4047 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

ACSL1 (D2H5) Rabbit mAb - 9189 from Cell Signaling Technology Prices $99.00, $246.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D2H5

ACSL1 (C-16) - sc-49008 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

ACSL1 (H-65) - sc-98925 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Anti-ACSL1 antibody - ab76702 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ACSL1 antibody - ab189939 from Abcam Prices $407.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-ACSL1 antibody - ab89854 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ACSL1 antibody - ab151989 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ACSL1 antibody - ab54638 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-ACSL1 antibody [EPR13498] - ab178419 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR13498

Anti-ACSL1 antibody [EPR13499] - ab177958 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR13499

Anti-FACL2 / ACSL1 Antibody (Internal) IHC-plus™ - LS-B8879 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-FACL2 / ACSL1 Antibody - LS-C121330 from LifeSpan Bioscience Prices $415.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-FACL2 / ACSL1 Antibody (N-Terminus, Biotin) - LS-C141950 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-FACL2 / ACSL1 Antibody (N-Terminus, DY650) - LS-C141951 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-FACL2 / ACSL1 Antibody (N-Terminus, DY488) - LS-C141952 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-FACL2 / ACSL1 Antibody (N-Terminus, HRP) - LS-C141953 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-FACL2 / ACSL1 Antibody (N-Terminus, DY550) - LS-C141954 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-FACL2 / ACSL1 Antibody (aa505-533, AP) - LS-C250718 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-FACL2 / ACSL1 Antibody (aa505-533, APC) - LS-C250719 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-FACL2 / ACSL1 Antibody (aa505-533) - LS-C319296 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-FACL2 / ACSL1 Antibody (aa74-123) - LS-C80023 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-FACL2 / ACSL1 Antibody (aa505-533, PE) - LS-C250722 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-FACL2 / ACSL1 Antibody (aa505-533, FITC) - LS-C250721 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-FACL2 / ACSL1 Antibody (clone 3G4) - LS-C197189 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3G4

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