Gene Symbol | HIST3H2BB |
---|---|
Entrez Gene | 128312 |
Alt Symbol | H2Bb |
Species | Human |
Gene Type | protein-coding |
Description | histone cluster 3, H2bb |
Other Description | H2B type 12|histone 3, H2bb|histone H2B type 3-B |
Swissprots | Q5TA30 Q3ZCP6 A4FU05 Q8N257 |
Accessions | AAN59962 EAW69879 Q8N257 AK091220 BAC03613 BC100855 AAI00856 BC100856 AAI00857 BC100857 AAI00858 BC100858 AAI00859 BC137467 AAI37468 BC137468 AAI37469 NM_175055 NP_778225 |
Function | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
Subcellular Location | Nucleus. Chromosome. |
Top Pathways | Systemic lupus erythematosus, Viral carcinogenesis, Alcoholism |