| Gene Symbol |
CPT1A
|
| Entrez Gene |
1374
|
| Alt Symbol |
CPT1, CPT1-L, L-CPT1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
carnitine palmitoyltransferase 1A (liver)
|
| Other Description |
CPT I|CPTI-L|carnitine O-palmitoyltransferase 1, liver isoform|carnitine O-palmitoyltransferase I, liver isoform|carnitine palmitoyltransferase I, liver
|
| Swissprots |
Q9BWK0 Q8TCU0 P50416
|
| Accessions |
CAD12625 CAD59673 EAW74721 EAW74722 P50416 AA632225 AJ420378 CAD12576 AK025307 AK172798 AK309464 AK314301 BAG36955 BC000185 AAH00185 BT009791 AAP88793 DB063502 L39211 AAC41748 X83113 XM_005273762 XP_005273819 XM_005273763 XP_005273820 NM_001031847 NP_001027017 NM_001876 NP_001867
|
| Function |
Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Plays an important role in triglyceride metabolism.
|
| Subcellular Location |
Mitochondrion outer membrane {ECO:0000269|PubMed:11350182, ECO:0000269|PubMed:14517221}; Multi- pass membrane protein {ECO:0000269|PubMed:11350182, ECO:0000269|PubMed:14517221}.
|
| Tissue Specificity |
Strong expression in kidney and heart, and lower in liver and skeletal muscle.
|
| Top Pathways |
Adipocytokine signaling pathway, PPAR signaling pathway, AMPK signaling pathway, Glucagon signaling pathway, Fatty acid degradation
|