Gene Symbol | CPT1A |
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Entrez Gene | 1374 |
Alt Symbol | CPT1, CPT1-L, L-CPT1 |
Species | Human |
Gene Type | protein-coding |
Description | carnitine palmitoyltransferase 1A (liver) |
Other Description | CPT I|CPTI-L|carnitine O-palmitoyltransferase 1, liver isoform|carnitine O-palmitoyltransferase I, liver isoform|carnitine palmitoyltransferase I, liver |
Swissprots | Q9BWK0 Q8TCU0 P50416 |
Accessions | CAD12625 CAD59673 EAW74721 EAW74722 P50416 AA632225 AJ420378 CAD12576 AK025307 AK172798 AK309464 AK314301 BAG36955 BC000185 AAH00185 BT009791 AAP88793 DB063502 L39211 AAC41748 X83113 XM_005273762 XP_005273819 XM_005273763 XP_005273820 NM_001031847 NP_001027017 NM_001876 NP_001867 |
Function | Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Plays an important role in triglyceride metabolism. |
Subcellular Location | Mitochondrion outer membrane {ECO:0000269|PubMed:11350182, ECO:0000269|PubMed:14517221}; Multi- pass membrane protein {ECO:0000269|PubMed:11350182, ECO:0000269|PubMed:14517221}. |
Tissue Specificity | Strong expression in kidney and heart, and lower in liver and skeletal muscle. |
Top Pathways | Adipocytokine signaling pathway, PPAR signaling pathway, AMPK signaling pathway, Glucagon signaling pathway, Fatty acid degradation |
CPTI CRISPR/Cas9 KO Plasmid (h) - sc-401811 from Santa Cruz Biotechnology
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CPTI HDR Plasmid (h) - sc-401811-HDR from Santa Cruz Biotechnology
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CPTI Double Nickase Plasmid (h) - sc-401811-NIC from Santa Cruz Biotechnology
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CPTI Double Nickase Plasmid (h2) - sc-401811-NIC-2 from Santa Cruz Biotechnology
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CPTI CRISPR Activation Plasmid (h) - sc-401811-ACT from Santa Cruz Biotechnology
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CPTI CRISPR Activation Plasmid (h2) - sc-401811-ACT-2 from Santa Cruz Biotechnology
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CPTI Lentiviral Activation Particles (h) - sc-401811-LAC from Santa Cruz Biotechnology
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CPTI Lentiviral Activation Particles (h2) - sc-401811-LAC-2 from Santa Cruz Biotechnology
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CPTI siRNA (h) - sc-40376 from Santa Cruz Biotechnology
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CPTI shRNA Plasmid (h) - sc-40376-SH from Santa Cruz Biotechnology
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CPTI shRNA (h) Lentiviral Particles - sc-40376-V from Santa Cruz Biotechnology
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CPTI-L siRNA (h) - sc-40380 from Santa Cruz Biotechnology
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CPTI-L shRNA Plasmid (h) - sc-40380-SH from Santa Cruz Biotechnology
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CPTI-L shRNA (h) Lentiviral Particles - sc-40380-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU041711 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1875 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1875 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04612 from Sigma-Aldrich
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CPT1A siRNA (Human) - CRH0962 from Cohesion Biosciences
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CPT1A - MBS8202604 from MyBioSource
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shRNA set against Human CPT1A (NM_001876.3) - SHH269001 from Creative biogene
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Human CPT1A siRNA - orb261464 from Biorbyt
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CPT1A shRNA Plasmid (Human) - CHH0962 from Cohesion Biosciences
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CPT1A miRNA 3'UTR clone - MiUTR3H-03450 from Creative biogene
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CPT1A miRNA 3'UTR clone - MiUTR4H-TG02324 from Creative biogene
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