| Gene Symbol |
PUM1
|
| Entrez Gene |
9698
|
| Alt Symbol |
HSPUM, PUMH, PUMH1, PUML1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
pumilio RNA-binding family member 1
|
| Other Description |
pumilio homolog 1|pumilio-1
|
| Swissprots |
E9PCJ0 Q5VXY7 Q53HH5 A8K6W4 D3DPN3 Q9HAN1 B4DG92 Q14671
|
| Accessions |
EAX07630 EAX07631 EAX07632 EAX07633 EAX07634 Q14671 AF315592 AAG31807 AK056662 AK096476 BAG53299 AK222605 BAD96325 AK291779 BAF84468 AK294477 BAG57703 AK300457 BAG62177 AL699026 BC013398 AAH13398 BX647437 CN402209 D43951 BAA07895 JF432347 ADZ15564 NM_001020658 NP_001018494 NM_014676 NP_055491
|
| Function |
Sequence-specific RNA-binding protein that negatively regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE). Capable of deadenylation-dependent and -independent modes of repression. May be required to support proliferation and self-renewal of stem cells. {ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:22955276}.
|
| Subcellular Location |
Cytoplasm {ECO:0000305}.
|
| Tissue Specificity |
Expressed in brain, heart, kidney, muscle, intestine and stomach. Not expressed in cerebellum, corpus callosum, caudate nucleus, hippocampus, medulla oblongata and putamen. Expressed in all fetal tissues tested. {ECO:0000269|PubMed:12459267}.
|