PUM1
| Gene Symbol | PUM1 |
|---|---|
| Entrez Gene | 9698 |
| Alt Symbol | HSPUM, PUMH, PUMH1, PUML1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | pumilio RNA-binding family member 1 |
| Other Description | pumilio homolog 1|pumilio-1 |
| Swissprots | E9PCJ0 Q5VXY7 Q53HH5 A8K6W4 D3DPN3 Q9HAN1 B4DG92 Q14671 |
| Accessions | EAX07630 EAX07631 EAX07632 EAX07633 EAX07634 Q14671 AF315592 AAG31807 AK056662 AK096476 BAG53299 AK222605 BAD96325 AK291779 BAF84468 AK294477 BAG57703 AK300457 BAG62177 AL699026 BC013398 AAH13398 BX647437 CN402209 D43951 BAA07895 JF432347 ADZ15564 NM_001020658 NP_001018494 NM_014676 NP_055491 |
| Function | Sequence-specific RNA-binding protein that negatively regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE). Capable of deadenylation-dependent and -independent modes of repression. May be required to support proliferation and self-renewal of stem cells. {ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:22955276}. |
| Subcellular Location | Cytoplasm {ECO:0000305}. |
| Tissue Specificity | Expressed in brain, heart, kidney, muscle, intestine and stomach. Not expressed in cerebellum, corpus callosum, caudate nucleus, hippocampus, medulla oblongata and putamen. Expressed in all fetal tissues tested. {ECO:0000269|PubMed:12459267}. |
Pumilio 1 CRISPR/Cas9 KO Plasmid (h) - sc-406309 from Santa Cruz Biotechnology
|
||||||||
Pumilio 1 HDR Plasmid (h) - sc-406309-HDR from Santa Cruz Biotechnology
|
||||||||
Pumilio 1 Double Nickase Plasmid (h) - sc-406309-NIC from Santa Cruz Biotechnology
|
||||||||
Pumilio 1 Double Nickase Plasmid (h2) - sc-406309-NIC-2 from Santa Cruz Biotechnology
|
||||||||
Pumilio 1 CRISPR Activation Plasmid (h) - sc-406309-ACT from Santa Cruz Biotechnology
|
||||||||
Pumilio 1 CRISPR Activation Plasmid (h2) - sc-406309-ACT-2 from Santa Cruz Biotechnology
|
||||||||
Pumilio 1 Lentiviral Activation Particles (h) - sc-406309-LAC from Santa Cruz Biotechnology
|
||||||||
Pumilio 1 Lentiviral Activation Particles (h2) - sc-406309-LAC-2 from Santa Cruz Biotechnology
|
||||||||
Pumilio 1 siRNA (h) - sc-62912 from Santa Cruz Biotechnology
|
||||||||
Pumilio 1 shRNA Plasmid (h) - sc-62912-SH from Santa Cruz Biotechnology
|
||||||||
Pumilio 1 shRNA (h) Lentiviral Particles - sc-62912-V from Santa Cruz Biotechnology
|
||||||||
PUM1 RNAi - H00009698-R01 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU001311 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN17735 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17735 from Sigma-Aldrich
|
||||||||
PUM1 siRNA (Human) - CRH6469 from Cohesion Biosciences
|
||||||||
PUM1 RNAi - H00009698-R02 from Novus Biologicals
|
||||||||
Pumilio 1 CRISPR/Cas9 KO Plasmid (h2) - sc-406309-KO-2 from Santa Cruz Biotechnology
|
||||||||
Pumilio 1 HDR Plasmid (h2) - sc-406309-HDR-2 from Santa Cruz Biotechnology
|
||||||||
shRNA set against Human PUM1 (NM_014676.2) - SHH387020 from Creative biogene
|
||||||||
shRNA set against Human PUM1(NM_001020658.1) - SHR154566 from Creative biogene
|
||||||||
shRNA set against Human PUM1(NM_014676.2) - SHR154584 from Creative biogene
|
||||||||
Human PUM1 siRNA - orb266971 from Biorbyt
|
||||||||
PUM1 shRNA Plasmid (Human) - CHH6469 from Cohesion Biosciences
|
||||||||
PUM1 miRNA 3'UTR clone - MiUTR1H-08490 from Creative biogene
|